TNFRSF25 (Tumor Necrosis Factor Receptor Superfamily Member 25), also known as LARD, APO3, DR3 or TNFR25, is a protein that in humans is encoded by the TNFRSF25 gene. Members of the mammalian tumor necrosis factor receptor(TNFR) family are cell-surface proteins that interact with a corresponding TNF-related ligand family. By fluorescence in situ hybridization, Marsters et al.(1996) mapped the gene to 1p36.3. Marsters et al.(1996) showed that ectopic expression of DR3 in mammalian cells triggered apoptosis and activated the transcription factor NF-kappa-B. They suggested that, like TNFR1, DR3 may regulate distinct signaling pathways in different cellular contexts.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the N-terminus of human Death receptor 3 (CPQDTFLAWENHHNSECARCQA) was used as the immunogen for this DR3 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
DR3
Uniprot
Q93038
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the DR3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.