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Home / Primary Antibodies / Polyclonal Antibodies

Cytochrome P450 2E1 Antibody

SKU : BHA17104526

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NSJ Bioreagents

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Mfr.No.	R31009
Clonality	Polyclonal
Description	Cytochrome P450 2E1, also known as P450IIE1, is a member of the P450IIE subfamily which is ethanol-inducible. It has at least one gene which is mapped to 10q24.3-qter, and a second is likely in rat and in man. Both the rat and human proteins encoded by this gene contain 493 amino acids and calculated molecular masses of 56,634 and 56,916 daltons, respectively. In addition, genetic polymorphisms in the 5-prime flanking region of the human P450IIE1 gene affected its binding of transacting factor and changed its transcriptional regulation, which may lead to interindividual differences of microsomal drug oxidation activity. Cytochrome P450 2E1 is an important enzyme for the catalysis of the conversion of ethanol to acetaldehyde and to acetate in humans,and it is also involved in the metabolism of nitrosamines. Due to the possible correlation of P450IIE1 genes with malignancy, clinical studies of RFLP patterns of these genes in cancer may be useful.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the N-terminus of mouse CYP2E1 (KNEFSGRGDIPVFQEYKNK) was used as the immunogen for this Cytochrome P450 2E1 antibody (100% rat homology).
Isotype	IgG
Predicted Reactivity	Mouse, Rat
Reactivity	Mouse, Rat
Recombinant	No

Antigen	Cytochrome P450 2E1
Uniprot	Q05421

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the Cytochrome P450 2E1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	IHC-P, WB
Dilution	Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17104526-1	R31009	100ug	$439		Add to Cart

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