Chemokine (C-X-C motif) ligand 4, is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. It belongs to the CXC chemokine family. The gene contains 3 exons spanning approximately 1 kb. It is encoded on a 10-kb EcoRI fragment of genomic DNA. By in situ hybridization, the gene is mapped to chromosome 4q12-q21. CXCL4s major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, the cytokine probably has a role in inflammation and wound repair.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids 85-101 (DLQAPLYKKIIKKLLES-human) were used as the immunogen for this CXCL4 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
CXCL4
Uniprot
P02776
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the CXCL4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Applications
WB, IHC-P
Dilution
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml