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Home / Primary Antibodies / Polyclonal Antibodies

COMT Antibody

SKU : BHA17104763

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Mfr.No.	R31326
Clonality	Polyclonal
Description	Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. It is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between the two forms reside within the N-termini.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the N-terminus of human Catechol O-methyltransferase (DKKGKIVDAVIQEHQ) was used as the immunogen for this COMT antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	COMT
Uniprot	P21964

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the COMT antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17104763-1	R31326	100ug	$439		Add to Cart

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