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Home / Primary Antibodies / Polyclonal Antibodies

Claudin 18 Antibody / CLDN18

SKU : BHA17119260

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NSJ Bioreagents

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Mfr.No.	RQ6848
Cellular Localization	cell junction, Cell membrane
Clonality	Polyclonal (rabbit origin)
Description	Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Host	Rabbit
Immunogen Region	Recombinant human protein (amino acids S31-V261) was used as the immunogen for the Claudin 18 antibody.
Isotype	Rabbit IgG
Reactivity	Rat, Human
Recombinant	No

Antigen	Claudin 18
Uniprot	P56856

Buffer	Lyophilized from 1X PBS with 2% Trehalose
Concentration	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format	Antigen affinity purified
Purification	Antigen affinity purified
Storage	After reconstitution, the Claudin 18 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Applications	Direct ELISA, FACS, IF, IHC-P, WB
Dilution	Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml,Immunofluorescence (FFPE): 5ug/ml,Flow cytometry: 1-3ug/million cells,Direct ELISA: 0.1-0.5ug/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119260	RQ6848	100ug	$439		Add to Cart

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