Protein CIP2A, also known as 'cancerous inhibitor of PP2A' and p90, is a protein that in humans is encoded by the KIAA1524 gene. It is required for the malignant cellular growth and for in vivo tumor formation. In accordance with the oncogenic role of CIP2A, overexpression promotes Ras-elicited cell growth and transforms immortalized human cells (HEK-TERVs). More recently CIP2A has been shown to regulate phosphorylation and activity of many other oncoproteins and to drive malignant cell growth and tumorigenesis in various human cancer types. Importantly, CIP2A deficient mice are viable, suggesting that targeting of oncogenic function of CIP2A would not result in serious side-effects.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids EVQKAQLEGRLEEKESLVKLQQEELNKHSHMIAMIH of human KIAA1524 were used as the immunogen for the CIP2A antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse
Reactivity
Mouse, Human
Recombinant
No
Antigen
CIP2A
Uniprot
Q8TCG1
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the CIP2A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.