Cholesteryl Ester Transfer Protein Plasma, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. CETP is also known as lipid transfer protein I(Day et al., 1994). Sparkes et al.(1987) used a CETP probe against DNA from a human/mouse somatic cell hybrid panel to assign the gene to chromosome 16. Because the role of CETP in atherosclerosis remained unclear, Okamoto et al.(2000) attempted to develop a potent, specific inhibitor. One inhibitor, JTT-705, forms a disulfide bond with CETP and increases high density lipoprotein (HDL) cholesterol, decreases non-HDL cholesterol, and inhibits the progression of atherosclerosis in rabbits.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of human Cholesteryl Ester Transfer Protein Plasma (PRPDQQHSVAYTFEE) was used as the immunogen for this CETP antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
CETP
Uniprot
P11597
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the CETP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.