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Home / Primary Antibodies / Polyclonal Antibodies

CENPB Antibody / Centromere protein B

SKU : BHA17119113

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NSJ Bioreagents

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Mfr.No.	RQ6699
Cellular Localization	Nuclear
Clonality	Polyclonal (rabbit origin)
Description	Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Host	Rabbit
Immunogen Region	Amino acids HLEHDLVHVTRKNHA from the human protein were used as the immunogen for the CENPB antibody.
Isotype	Rabbit IgG
Reactivity	Human
Recombinant	No

Antigen	CENPB
Uniprot	P07199

Buffer	Lyophilized from 1X PBS with 2% Trehalose
Concentration	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format	Antigen affinity purified
Purification	Antigen affinity purified
Storage	After reconstitution, the CENPB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Applications	FACS, IF, WB
Dilution	Western blot: 1-2ug/ml,Immunofluorescence (FFPE): 5ug/ml,Flow cytometry: 1-3ug/million cells

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119113	RQ6699	100ug	$439		Add to Cart

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