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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ZAP70 Antibody Picoband®

SKU : BHA21000867

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Mfr.No.	PB9968, PB9968-10ug, PB9968-Biotin, PB9968-Cy3, PB9968-Dylight488, PB9968-Dylight550, PB9968-Dylight594, PB9968-FITC, PB9968-HRP, PB9968-APC, PB9968-PE, PB9968-iFluor647, PB9968-carrier-free
Alternative Names	Tyrosine-protein kinase ZAP-70
Background	ZAP-70 (Zeta-chain-associated protein kinase 70) encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ZAP70 Antibody Picoband® catalog # PB9968. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of pri
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human ZAP70, different from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tyrosine-protein kinase ZAP-70;2.7.10.2;70 kDa zeta-chain associated protein;Syk-related tyrosine kinase;ZAP70;SRK;
Tissue Specificity	Expressed in T- and natural killer cells. Also present in early thymocytes and pro/pre B-cells. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P43403
Gene Id	7535
Gene Name	ZAP70
Subcellular Location	Cytoplasm . Cell membrane ; Peripheral membrane protein . In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat

Reference	1. Lupher ML, Reedquist KA, Miyake S, Langdon WY, Band H (Sep 1996). "A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts ly and selectively with ZAP-70 in T cells".The Joual of Biological Chemistry 271 (39): 240638. 2. Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ (Mar 1999). "Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase". Nature 398 (6722): 8490. 3. Neumeister EN, Zhu Y, Richard S, Terhorst C, Chan AC, Shaw AS (Jun 1995). "Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins". Molecular and Cellular Biology 15 (6): 31718.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000867-1	PB9968	100 ug	-	$370		Add to Cart
BHA21000867-2	PB9968-10ug	10 ug	Sample	$99		Add to Cart
BHA21000867-3	PB9968-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000867-4	PB9968-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000867-5	PB9968-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000867-6	PB9968-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000867-7	PB9968-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000867-8	PB9968-FITC	100 ug	FITC	$570		Add to Cart
BHA21000867-9	PB9968-HRP	100 ug	HRP	$570		Add to Cart
BHA21000867-10	PB9968-APC	100 ug	APC	$670		Add to Cart
BHA21000867-11	PB9968-PE	100 ug	PE	$670		Add to Cart
BHA21000867-12	PB9968-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000867-13	PB9968-carrier-free	100 ug	carrier-free	$370		Add to Cart

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