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Home / Primary Antibodies / Polyclonal Antibodies

Anti-YB1/YBX1 Antibody Picoband®

SKU : BHA21007032

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Mfr.No.	PA1758, PA1758-10ug, PA1758-Biotin, PA1758-Cy3, PA1758-Dylight488, PA1758-Dylight550, PA1758-Dylight594, PA1758-FITC, PA1758-HRP, PA1758-APC, PA1758-PE, PA1758-iFluor647, PA1758-carrier-free
Alternative Names	Nuclease-sensitive element-binding protein 1
Background	YBX1 (Y box binding protein 1), commonly referred to as "YB-1" by researchers, is a human protein. YB1 binding has an absolute requirement for the CCAAT box and relative specificity for the Y box. It has a molecular mass of 35,414 and contains 18% basic residues and putative nuclear localization signals. The YBX1 gene is mapped on 1p34.2. Ybx1 was highly expressed in mouse erythroid myeloid lymphoid clone-1 (EML), a hematopoietic precursor cell line, but that it was downregulated in myeloid progenitors and in Gmcsf-treated EML cells during myeloid differentiation. Ybx1 was expressed at high levels in myeloid leukemic cells at different developmental stages. Knockdown of YBX1 in a human leukemic cell line inhibited proliferation ability, induced apoptosis, and induced megakaryocytic differentiation in response to arsenic trioxide treatment. YBX1 is downregulated during myeloid differentiation and aberrant YBX1 expression in leukemic cells may contribute to leukemia development by blocking differentiation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-YB1/YBX1 Antibody catalog # PA1758. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Mediates pre-mRNA alteative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA an
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human YB1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Nuclease-sensitive element-binding protein 1;CCAAT-binding transcription factor I subunit A;CBF-A;DNA-binding protein B;DBPB;Enhancer factor I subunit A;EFI-A;Y-box transcription factor;Y-box-binding protein 1;YB-1;YBX1;NSEP1, YB1;
Tissue Specificity	In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T- cell lines Peer, MOLT-4, HSB and YT. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P67809
Gene Name	YBX1
Sequence	Contains 1 CSD (cold-shock) domain.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic granule . Secreted. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Bhullar, J., Sollars, V. E. YBX1 expression and function in early hematopoiesis and leukemic cells. Immunogenetics 63: 337-350, 2011.<br /><br />2. Fukada, T., Tonks, N. K. Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling. EMBO J. 22: 479-493, 2003.<br /><br />3. Makino, Y., Ohga, T., Toh, S., Koike, K., Okumura, K., Wada, M., Kuwano, M., Kohno, K. Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter. Nucleic Acid Res. 24: 1873-1878, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007032-1	PA1758	-	100 ug	$370		Add to Cart
BHA21007032-2	PA1758-10ug	Sample	10 ug	$99		Add to Cart
BHA21007032-3	PA1758-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007032-4	PA1758-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007032-5	PA1758-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007032-6	PA1758-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007032-7	PA1758-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007032-8	PA1758-FITC	FITC	100 ug	$570		Add to Cart
BHA21007032-9	PA1758-HRP	HRP	100 ug	$570		Add to Cart
BHA21007032-10	PA1758-APC	APC	100 ug	$670		Add to Cart
BHA21007032-11	PA1758-PE	PE	100 ug	$670		Add to Cart
BHA21007032-12	PA1758-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007032-13	PA1758-carrier-free	carrier-free	100 ug	$370		Add to Cart

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