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Home / Primary Antibodies / Polyclonal Antibodies

Anti-YAP1 Antibody Picoband®

SKU : BHA21000866

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Mfr.No.	PB9967, PB9967-10ug, PB9967-Biotin, PB9967-Cy3, PB9967-Dylight488, PB9967-Dylight550, PB9967-Dylight594, PB9967-FITC, PB9967-HRP, PB9967-APC, PB9967-PE, PB9967-iFluor647, PB9967-carrier-free
Alternative Names	Transcriptional coactivator YAP1
Background	YAP1, also known as YAP or YAP65, is a potent oncogene, which is amplified in various human cancers. This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. It is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alteative splicing results in multiple transcript variants encoding different isoforms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-YAP1 Antibody Picoband® catalog # PB9967. Tested in Flow Cytometry, IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferat
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human YAP1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Transcriptional coactivator YAP1;Yes-associated protein 1;Protein yorkie homolog;Yes-associated protein YAP65 homolog;YAP1;YAP65;
Tissue Specificity	Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level). .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P46937
Gene Id	10413
Gene Name	YAP1
Subcellular Location	Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IP, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry, 2-5ug/ml, Human Immunocytochemistry/Immunofluorescence, 5ug/ml, Human Immunoprecipitation, 0.5-2 ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Huang, J., Wu, S., Barrera, J., Matthews, K., Pan, D. (2005). "The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP". Cell122 (3): 42134. 2. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA. (2006). "Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon". Proc Natl Acad Sci U S A. 103 (33): 1240512410. 3. Sudol M (1994). "Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product". Oncogene 9 (8): 21452152.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000866-1	PB9967	100 ug	-	$370		Add to Cart
BHA21000866-2	PB9967-10ug	10 ug	Sample	$99		Add to Cart
BHA21000866-3	PB9967-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000866-4	PB9967-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000866-5	PB9967-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000866-6	PB9967-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000866-7	PB9967-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000866-8	PB9967-FITC	100 ug	FITC	$570		Add to Cart
BHA21000866-9	PB9967-HRP	100 ug	HRP	$570		Add to Cart
BHA21000866-10	PB9967-APC	100 ug	APC	$670		Add to Cart
BHA21000866-11	PB9967-PE	100 ug	PE	$670		Add to Cart
BHA21000866-12	PB9967-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000866-13	PB9967-carrier-free	100 ug	carrier-free	$370		Add to Cart

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