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Home / Primary Antibodies / Polyclonal Antibodies

Anti-XIAP Antibody Picoband®

SKU : BHA21006853

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Mfr.No.	PA1512, PA1512-10ug, PA1512-Biotin, PA1512-Cy3, PA1512-Dylight488, PA1512-Dylight550, PA1512-Dylight594, PA1512-FITC, PA1512-HRP, PA1512-APC, PA1512-PE, PA1512-iFluor647, PA1512-carrier-free
Alternative Names	E3 ubiquitin-protein ligase XIAP
Background	BIRC4, baculoviral IAP repeat-containing protein 4 is also known as XIAP (X-linked inhibitor of apoptosis protein). The BIRC4 gene comprises 6 exons. This gene is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alteate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-XIAP Antibody catalog # PA1512. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a caspa
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human XIAP, different from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	E3 ubiquitin-protein ligase XIAP;6.3.2.-;Baculoviral IAP repeat-containing protein 4;IAP-like protein;ILP;hILP;Inhibitor of apoptosis protein 3;IAP-3;hIAP-3;hIAP3;X-linked inhibitor of apoptosis protein;X-linked IAP;XIAP;API3, BIRC4, IAP3;
Tissue Specificity	Ubiquitous, except peripheral blood leukocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P98170
Gene Name	XIAP
Sequence	Belongs to the IAP family.
Subcellular Location	Cytoplasm. Nucleus. TLE3 promotes its nuclear localization.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat <br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Cummins, J. M., Kohli, M., Rago, C., Kinzler, K. W., Vogelstein, B., Bunz, F.X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.Cancer Res. 64: 3006-3008, 2004.<br /><br />2. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., Reed, J. C.X-linked IAP is a inhibitor of cell-death proteases.Nature 388: 300-304, 1997.<br /><br />3. Kim, J., Park, J., Choi, S., Chi, S.-G., Mowbray, A. L., Jo, H., Park, H.X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival.Circ. Res. 102: 896-904, 2008.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006853-1	PA1512	-	100 ug	$370		Add to Cart
BHA21006853-2	PA1512-10ug	Sample	10 ug	$99		Add to Cart
BHA21006853-3	PA1512-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006853-4	PA1512-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006853-5	PA1512-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006853-6	PA1512-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006853-7	PA1512-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006853-8	PA1512-FITC	FITC	100 ug	$570		Add to Cart
BHA21006853-9	PA1512-HRP	HRP	100 ug	$570		Add to Cart
BHA21006853-10	PA1512-APC	APC	100 ug	$670		Add to Cart
BHA21006853-11	PA1512-PE	PE	100 ug	$670		Add to Cart
BHA21006853-12	PA1512-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006853-13	PA1512-carrier-free	carrier-free	100 ug	$370		Add to Cart

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