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Home / Primary Antibodies / Polyclonal Antibodies

Anti-XBP1 Antibody Picoband®

SKU : BHA21000357

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Mfr.No.	PB9463, PB9463-10ug, PB9463-Biotin, PB9463-Cy3, PB9463-Dylight488, PB9463-Dylight550, PB9463-Dylight594, PB9463-FITC, PB9463-HRP, PB9463-APC, PB9463-PE, PB9463-iFluor647, PB9463-carrier-free
Alternative Names	X-box-binding protein 1
Background	XBP1, also known as X-box binding protein 1, is a protein which in humans is encoded by the XBP1 gene. It encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1 (S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1 (U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1 (S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-XBP1 Antibody Picoband® catalog # PB9463. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such a
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human XBP1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	29 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	X-box-binding protein 1 ;XBP-1 ;Tax-responsive element-binding protein 5 ;TREB-5 ;X-box-binding protein 1, cytoplasmic form ;X-box-binding protein 1, luminal form ;XBP1 ;TREB5 , XBP2 ;
Tissue Specificity	Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P17861
Gene Id	7494
Gene Name	XBP1
Sequence	Belongs to the bZIP family.
Subcellular Location	Endoplasmic reticulum . Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. "Entrez Gene: XBP1 X-box binding protein 1". 2. Ono SJ, Liou HC, Davidon R, Strominger JL, Glimcher LH (May 1991). "Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 430912. 3. Yoshida H, Nadanaka S, Sato R, Mori K (2006). "XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells". Cell Structure and Function 31 (2): 11725.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000357-1	PB9463	100 ug	-	$370		Add to Cart
BHA21000357-2	PB9463-10ug	10 ug	Sample	$99		Add to Cart
BHA21000357-3	PB9463-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000357-4	PB9463-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000357-5	PB9463-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000357-6	PB9463-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000357-7	PB9463-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000357-8	PB9463-FITC	100 ug	FITC	$570		Add to Cart
BHA21000357-9	PB9463-HRP	100 ug	HRP	$570		Add to Cart
BHA21000357-10	PB9463-APC	100 ug	APC	$670		Add to Cart
BHA21000357-11	PB9463-PE	100 ug	PE	$670		Add to Cart
BHA21000357-12	PB9463-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000357-13	PB9463-carrier-free	100 ug	carrier-free	$370		Add to Cart

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