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Home / Primary Antibodies / Polyclonal Antibodies

Anti-WAC Antibody Picoband®

SKU : BHA21002795

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Mfr.No.	A04941-1, A04941-1-10ug, A04941-1-Biotin, A04941-1-Cy3, A04941-1-Dylight488, A04941-1-Dylight550, A04941-1-Dylight594, A04941-1-FITC, A04941-1-HRP, A04941-1-APC, A04941-1-PE, A04941-1-iFluor647, A04941-1-carrier-free
Alternative Names	REC8 meiotic recombination protein
Background	The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-WAC Antibody Picoband® catalog # A04941-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromer
Host	Rabbit
Immunogen Region	E.coli-derived human WAC recombinant protein (Position: Q459-V647).
Isotype	Rabbit IgG
Molecular Weight	85 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Meiotic recombination protein REC8 homolog; Cohesin Rec8p; REC8; REC8L1
Tissue Specificity	Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	Q9BTA9
Gene Id	51322
Gene Name	WAC
Subcellular Location	Nucleus. Chromosome. Centromere.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 4ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. DeSanto, C., D'Aco, K., Araujo, G. C., Shannon, N., DDD Study, Veon, H., Rahrig, A., Monaghan, K. G., Niu, Z., Vitazka, P., Dodd, J., Tang, S., and 9 others. WAC loss-of-function mutations cause a recognisable syndrome characterised by dysmorphic features, developmental delay and hypotonia and recapitulate 10p11.23 microdeletion syndrome. J. Med. Genet. 52: 754-761, 2015. <br /><br />2. Nagase, T., Nakayama, M., Nakajima, D., Kikuno, R., Ohara, O. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001. <br /><br />3. Xu, G. M., Aaout, M. A. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Genomics 79: 87-94, 2002.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002795-1	A04941-1	-	100 ug	$370		Add to Cart
BHA21002795-2	A04941-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002795-3	A04941-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002795-4	A04941-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002795-5	A04941-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002795-6	A04941-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002795-7	A04941-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002795-8	A04941-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002795-9	A04941-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002795-10	A04941-1-APC	APC	100 ug	$670		Add to Cart
BHA21002795-11	A04941-1-PE	PE	100 ug	$670		Add to Cart
BHA21002795-12	A04941-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002795-13	A04941-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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