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Home / Primary Antibodies / Polyclonal Antibodies

Anti-VRK1 Antibody Picoband®

SKU : BHA21000807

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Mfr.No.	PB9907, PB9907-10ug, PB9907-Biotin, PB9907-Cy3, PB9907-Dylight488, PB9907-Dylight550, PB9907-Dylight594, PB9907-FITC, PB9907-HRP, PB9907-APC, PB9907-PE, PB9907-iFluor647, PB9907-carrier-free
Alternative Names	Serine/threonine-protein kinase VRK1
Background	Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene. This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. It is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-VRK1 Antibody Picoband® catalog # PB9907. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18'
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human VRK1, different from the related mouse sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Serine/threonine-protein kinase VRK1;2.7.11.1;Vaccinia-related kinase 1;VRK1;
Tissue Specificity	Widely expressed. Highly expressed in fetal liver, testis and thymus. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q99986
Gene Id	7443
Gene Name	VRK1
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle . Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. "Entrez Gene: VRK1 vaccinia related kinase 1". 2. Nezu J, Oku A, Jones MH, Shimane M (Feb 1998). "Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase". Genomics 45 (2): 32731.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000807-1	PB9907	100 ug	-	$370		Add to Cart
BHA21000807-2	PB9907-10ug	10 ug	Sample	$99		Add to Cart
BHA21000807-3	PB9907-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000807-4	PB9907-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000807-5	PB9907-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000807-6	PB9907-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000807-7	PB9907-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000807-8	PB9907-FITC	100 ug	FITC	$570		Add to Cart
BHA21000807-9	PB9907-HRP	100 ug	HRP	$570		Add to Cart
BHA21000807-10	PB9907-APC	100 ug	APC	$670		Add to Cart
BHA21000807-11	PB9907-PE	100 ug	PE	$670		Add to Cart
BHA21000807-12	PB9907-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000807-13	PB9907-carrier-free	100 ug	carrier-free	$370		Add to Cart

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