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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Versican/VCAN Antibody Picoband®

SKU : BHA21000347

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Mfr.No.	PB9453, PB9453-10ug, PB9453-Biotin, PB9453-Cy3, PB9453-Dylight488, PB9453-Dylight550, PB9453-Dylight594, PB9453-FITC, PB9453-HRP, PB9453-APC, PB9453-PE, PB9453-iFluor647, PB9453-carrier-free
Alternative Names	Versican core protein
Background	Versican (VCAN), also known as CSPG2, is a large extracellular matrix proteoglycan that is present in a variety of human tissues. Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa. The Versican gene is mapped on 5q14.2-q14.3. The human versican gene contains 15 exons spanning more than 90 kb. The distribution of versican by using affinity-purified polyclonal antibodies that recognize the core protein of the prominent versican splice variants V0 and V1. Versican staining was noted in the central and peripheral nervous system, in the basal layer of the epidermis, and on the luminal surface of some glandular epithelia. Biochemical purification of LLC-conditioned medium led to identification of the extracellular matrix proteoglycan versican, which is upregulated in many human tumors including lung cancer, as a macrophage activator that acts through TLR2 and its coreceptors TLR6 and CD14. By activating TLR2:TLR6 complexes and inducing TNF-alpha secretion by myeloid cells, versican strongly enhances LLC metastatic growth.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Versican/VCAN Antibody Picoband® catalog # PB9453. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Versican, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	373 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Versican core protein;Chondroitin sulfate proteoglycan core protein 2;Chondroitin sulfate proteoglycan 2;Glial hyaluronate-binding protein;GHAP;Large fibroblast proteoglycan;PG-M;VCAN;CSPG2;
Tissue Specificity	Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P13611
Gene Id	1462
Gene Name	VCAN
Sequence	Belongs to the aggrecan/versican proteoglycan family.
Subcellular Location	Secreted, extracellular space, extracellular matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human

Reference	1. Bode-Lesniewska, B., Dours-Zimmermann, M. T., Odermatt, B. F., Briner, J., Heitz, P. U., Zimmermann, D. R. Distribution of the large aggregating proteoglycan versican in adult human tissues. J. Histochem. Cytochem. 44: 303-312, 1996. 2. Dours-Zimmermann, M. T., Zimmermann, D. R. A novel glycosaminoglycan attachment domain identified in two alteative splice variants of human versican. J. Biol. Chem. 269: 32992-32998, 1994. 3. Naso, M. F., Morgan, J. L., Buchberg, A. M., Siracusa, L. D., Iozzo, R. V. Expression patte and mapping of the murine versican gene (Cspg2) to chromosome 13. Genomics 29: 297-300, 1995.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000347-1	PB9453	100 ug	-	$370		Add to Cart
BHA21000347-2	PB9453-10ug	10 ug	Sample	$99		Add to Cart
BHA21000347-3	PB9453-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000347-4	PB9453-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000347-5	PB9453-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000347-6	PB9453-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000347-7	PB9453-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000347-8	PB9453-FITC	100 ug	FITC	$570		Add to Cart
BHA21000347-9	PB9453-HRP	100 ug	HRP	$570		Add to Cart
BHA21000347-10	PB9453-APC	100 ug	APC	$670		Add to Cart
BHA21000347-11	PB9453-PE	100 ug	PE	$670		Add to Cart
BHA21000347-12	PB9453-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000347-13	PB9453-carrier-free	100 ug	carrier-free	$370		Add to Cart

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