Anti-VEGF Receptor 2 antibody (STJ110008)

Product Description

The mammalian urinary bladder epithelium (urothelium) performs the important function of storing urine for extended periods, while maintaining the urine composition similar to that delivered by the kidneys ^[1]. The importance of the barrier function of the urothelium is illustrated by infectious cystitis. The loss of the barrier function results in the movement of urinary constituents into the lamina propria and underlying muscle layers, resulting in suprapubic and lower back pain and frequent, urgent, and painful voiding ^[2].

iXCells Biotechnologies provides high quality HBIEpC, which are isolated from normal human bladder and cryopreserved at P2, with >0.5 million cells in each vial. HAEpC express cytokeratin-18 and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HBIEpc can further expand no more than 3 passages in Epithelial Cell Growth Medium (Cat# MD-0041) under the condition suggested by iXCells Biotechnologies.

Figure 1. Human Bladder Epithelial Cells (HBlEpC). (A) Phase contrast image of HPRTEpC. (B) Immunofluorescence staining with antibody against ZO-1 (B).

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References

[1] Harry Horsley, Dhanuson Dharmasena, James Malone-Lee & Jennifer L. Rohn. (2018) “A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infection”. Scientific Reports, 8:1238.

[2] Hattori, S., K. Kojima, K. Minoshima, M. Yamaha, M. Horie, T. Sawamura, A. Kikuchi, and T. Deguchi. 2014. Detection of Bladder Cancer by Measuring CD44v6 Expression in Urine With Real-time Quantitative Reverse Transcription Polymerase Chain Reaction. Urology, 83:1443.e9-1443.e15.

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