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Home / Primary Antibodies / Polyclonal Antibodies

Anti-UHRF1 Antibody Picoband®

SKU : BHA21000805

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Mfr.No.	PB9905, PB9905-10ug, PB9905-Biotin, PB9905-Cy3, PB9905-Dylight488, PB9905-Dylight550, PB9905-Dylight594, PB9905-FITC, PB9905-HRP, PB9905-APC, PB9905-PE, PB9905-iFluor647, PB9905-carrier-free
Alternative Names	E3 ubiquitin-protein ligase UHRF1
Background	Ubiquitin-like, containing PHD and RING finger domains, 1 is a protein which in humans is encoded by the UHRF1 gene. This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-UHRF1 Antibody Picoband® catalog # PB9905. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human UHRF1, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	100 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	E3 ubiquitin-protein ligase UHRF1;6.3.2.-;Inverted CCAAT box-binding protein of 90 kDa;Nuclear protein 95;Nuclear zinc finger protein Np95;HuNp95;hNp95;RING finger protein 106;Transcription factor ICBP90;Ubiquitin-like PHD and RING finger domain-containing protein 1;hUHRF1;Ubiquitin-like-containing PHD and RING finger domains protein 1;UHRF1;ICBP90, NP95, RNF106;
Tissue Specificity	Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q96T88
Gene Id	29128
Gene Name	UHRF1
Subcellular Location	Nucleus . Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. "Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1". 2. Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C (Jan 2000)."ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression".Cancer Research 60 (1): 1218.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000805-1	PB9905	100 ug	-	$370		Add to Cart
BHA21000805-2	PB9905-10ug	10 ug	Sample	$99		Add to Cart
BHA21000805-3	PB9905-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000805-4	PB9905-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000805-5	PB9905-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000805-6	PB9905-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000805-7	PB9905-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000805-8	PB9905-FITC	100 ug	FITC	$570		Add to Cart
BHA21000805-9	PB9905-HRP	100 ug	HRP	$570		Add to Cart
BHA21000805-10	PB9905-APC	100 ug	APC	$670		Add to Cart
BHA21000805-11	PB9905-PE	100 ug	PE	$670		Add to Cart
BHA21000805-12	PB9905-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000805-13	PB9905-carrier-free	100 ug	carrier-free	$370		Add to Cart

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