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Home / Primary Antibodies / Polyclonal Antibodies

Anti-UBE1C/UBA3 Antibody Picoband®

SKU : BHA21000734

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Mfr.No.	PB9838, PB9838-10ug, PB9838-Biotin, PB9838-Cy3, PB9838-Dylight488, PB9838-Dylight550, PB9838-Dylight594, PB9838-FITC, PB9838-HRP, PB9838-APC, PB9838-PE, PB9838-iFluor647, PB9838-carrier-free
Alternative Names	NEDD8-activating enzyme E1 catalytic subunit
Background	NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, an ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alteatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-UBE1C/UBA3 Antibody Picoband® catalog # PB9838. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AM
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human UBE1C, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	52 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	NEDD8-activating enzyme E1 catalytic subunit;6.3.2.-;NEDD8-activating enzyme E1C;Ubiquitin-activating enzyme E1C;Ubiquitin-like modifier-activating enzyme 3;Ubiquitin-activating enzyme 3;UBA3;UBE1C;
Tissue Specificity	Ubiquitously expressed. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q8TBC4
Gene Id	9039
Gene Name	UBA3
Subcellular Location	Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. "Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)". 2. Bohnsack, R. N., Haas, A. L. Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. J. Biol. Chem. 278: 26823-26830, 2003. 3. Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S (August 1998). "A new NEDD8-ligating system for cullin-4A". Genes Dev 12 (15): 22638.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000734-1	PB9838	100 ug	-	$370		Add to Cart
BHA21000734-2	PB9838-10ug	10 ug	Sample	$99		Add to Cart
BHA21000734-3	PB9838-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000734-4	PB9838-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000734-5	PB9838-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000734-6	PB9838-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000734-7	PB9838-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000734-8	PB9838-FITC	100 ug	FITC	$570		Add to Cart
BHA21000734-9	PB9838-HRP	100 ug	HRP	$570		Add to Cart
BHA21000734-10	PB9838-APC	100 ug	APC	$670		Add to Cart
BHA21000734-11	PB9838-PE	100 ug	PE	$670		Add to Cart
BHA21000734-12	PB9838-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000734-13	PB9838-carrier-free	100 ug	carrier-free	$370		Add to Cart

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