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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TRIF/TICAM1 Antibody Picoband®

SKU : BHA21007151

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Mfr.No.	PA1902, PA1902-10ug, PA1902-Biotin, PA1902-Cy3, PA1902-Dylight488, PA1902-Dylight550, PA1902-Dylight594, PA1902-FITC, PA1902-HRP, PA1902-APC, PA1902-PE, PA1902-iFluor647, PA1902-carrier-free
Alternative Names	TIR domain-containing adapter molecule 1
Background	TICAM (TIR DOMAIN-CONTAINING ADAPTOR MOLECULE 1), also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al. (2003) mapped the TICAM1 gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al. (2003) showed that TICAM1 interacts specifically with TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TICAM1 mediates dsRNA activation of IFNB, through either NFKB, AP1, or IRF3. TICAM1 activation of NFKB was found to occur predominantly through IRAK1 rather than IRAK2. Small interfering (si)RNA blockage of TICAM1, just upstream of the TIR domain, reduced IFNB production in response to dsRNA.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TRIF/TICAM1 Antibody catalog # PA1902. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF rec
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TRIF.
Isotype	Rabbit IgG
Molecular Weight	110 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	TIR domain-containing adapter molecule 1;TICAM-1;Proline-rich, vinculin and TIR domain-containing protein B;Putative NF-kappa-B-activating protein 502H;Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta;MyD88-3;TIR domain-containing adapter protein inducing IFN-beta;TICAM1;PRVTIRB, TRIF;
Tissue Specificity	Ubiquitously expressed but with higher levels in liver. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q8IUC6
Gene Name	TICAM1
Sequence	Contains 1 TIR domain.
Subcellular Location	Cytoplasmic vesicle, autophagosome . Colocalizes with UBQLN1 in the autophagosome. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human, -<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Carty, M., Goodbody, R., Schroder, M., Stack, J., Moynagh, P. N., Bowie, A. G.The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.Nature Immun. 7: 1074-1081, 2006.<br /><br />2. Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., Seya, T.TICAM-I, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.Nature Immun. 4: 161-167, 2003.<br /><br />3. Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., Akira, S.Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.J. Immun. 169: 6668-6672, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007151-1	PA1902	-	100 ug	$370		Add to Cart
BHA21007151-2	PA1902-10ug	Sample	10 ug	$99		Add to Cart
BHA21007151-3	PA1902-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007151-4	PA1902-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007151-5	PA1902-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007151-6	PA1902-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007151-7	PA1902-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007151-8	PA1902-FITC	FITC	100 ug	$570		Add to Cart
BHA21007151-9	PA1902-HRP	HRP	100 ug	$570		Add to Cart
BHA21007151-10	PA1902-APC	APC	100 ug	$670		Add to Cart
BHA21007151-11	PA1902-PE	PE	100 ug	$670		Add to Cart
BHA21007151-12	PA1902-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007151-13	PA1902-carrier-free	carrier-free	100 ug	$370		Add to Cart

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