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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TREX1 Antibody Picoband®

SKU : BHA21000645

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Mfr.No.	PB9748, PB9748-10ug, PB9748-Biotin, PB9748-Cy3, PB9748-Dylight488, PB9748-Dylight550, PB9748-Dylight594, PB9748-FITC, PB9748-HRP, PB9748-APC, PB9748-PE, PB9748-iFluor647, PB9748-carrier-free
Alternative Names	Three-prime repair exonuclease 1
Background	Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene. This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TREX1 Antibody Picoband® catalog # PB9748. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroeleme
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human TREX1, different from the related mouse sequence by four amino acids.
Isotype	Rabbit IgG
Molecular Weight	33 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Three-prime repair exonuclease 1;3.1.11.2;3'-5' exonuclease TREX1;DNase III;TREX1;
Tissue Specificity	Detected in thymus, spleen, liver, brain, heart, small intestine and colon. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9NSU2
Gene Id	11277
Gene Name	TREX1
Subcellular Location	Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Retained in the cytoplasm through the C-terminal region (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci. Translocation to the nucleus also occurs during GZMA-mediated cell death. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human

Reference	1. "Entrez Gene: TREX1 three prime repair exonuclease 1". 2. Mazur DJ, Perrino FW (Aug 1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases". J Biol Chem 274 (28): 1965560.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000645-1	PB9748	100 ug	-	$370		Add to Cart
BHA21000645-2	PB9748-10ug	10 ug	Sample	$99		Add to Cart
BHA21000645-3	PB9748-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000645-4	PB9748-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000645-5	PB9748-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000645-6	PB9748-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000645-7	PB9748-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000645-8	PB9748-FITC	100 ug	FITC	$570		Add to Cart
BHA21000645-9	PB9748-HRP	100 ug	HRP	$570		Add to Cart
BHA21000645-10	PB9748-APC	100 ug	APC	$670		Add to Cart
BHA21000645-11	PB9748-PE	100 ug	PE	$670		Add to Cart
BHA21000645-12	PB9748-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000645-13	PB9748-carrier-free	100 ug	carrier-free	$370		Add to Cart

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