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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TREM1 Antibody

SKU : BHA21001395

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Mfr.No.	A02135-3, A02135-3-10ug, A02135-3-Biotin, A02135-3-Cy3, A02135-3-Dylight488, A02135-3-Dylight550, A02135-3-Dylight594, A02135-3-FITC, A02135-3-HRP, A02135-3-APC, A02135-3-PE, A02135-3-iFluor647, A02135-3-carrier-free
Alternative Names	triggering receptor expressed on myeloid cells 1
Background	Trem1, Triggering receptor expressed on myeloid cells-1, is encoded by Trem1 gene. The expression of Trem1 is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. Trem1 is a 30-kD glycoprotein that is reduced to 26 kD by deglycosylation, in agreement with the predicted molecular mass. The Trem1 gene which contains 4 exons maps to chromosome 6p21.1, within a TREM gene cluster and the mouse Trem1 gene maps to chromosome 17 in a region that shows homology of synteny to human chromosome 6. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide (LPS), gram-negative bacteria, and fungi. Cross-linking of Trem1 on neutrophils induces interleukin-8 (IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1 (MCP1, or SCYA2) and tumor necrosis factor (TNF); MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Trem1 engagement also induces upregulation of adhesion molecules (e.g., ITGB1) and costimulatory molecules (e.g., CD40). Trem1 is associated with DAP12 (TYROBP), a molecule frequently associated with activating receptors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TREM1 Antibody Picoband® catalog # A02135-3. Tested in ELISA applications. This antibody reacts with Human.
Function	Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered b
Host	Rabbit
Immunogen Region	E. coli-derived huamn TREM1 recombinant protein (Position: A21-R200).
Isotype	Rabbit IgG
Molecular Weight	26 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Triggering receptor expressed on myeloid cells 1; TREM-1; Triggering receptor expressed on monocytes 1; CD354; TREM1;
Tissue Specificity	Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	TREM1: Q9NP99
Gene Id	54210
Gene Name	TREM1
Subcellular Location	Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA
Description	ELISA Capture (Matched Antibody Pair), 2-8ug/ml<br>

Reference	1. Allcock, R. J. N., Barrow, A. D., Forbes, S., Beck, S., Trowsdale, J.The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.Europ. J. Immun. 33: 567-577, 2003.<br /><br />2. Bouchon, A., Dietrich, J., Colonna, M.Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.J. Immun. 164: 4991-4995, 2000.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001395-1	A02135-3	100 ug	-	$370		Add to Cart
BHA21001395-2	A02135-3-10ug	10 ug	Sample	$99		Add to Cart
BHA21001395-3	A02135-3-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001395-4	A02135-3-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001395-5	A02135-3-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001395-6	A02135-3-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001395-7	A02135-3-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001395-8	A02135-3-FITC	100 ug	FITC	$570		Add to Cart
BHA21001395-9	A02135-3-HRP	100 ug	HRP	$570		Add to Cart
BHA21001395-10	A02135-3-APC	100 ug	APC	$670		Add to Cart
BHA21001395-11	A02135-3-PE	100 ug	PE	$670		Add to Cart
BHA21001395-12	A02135-3-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001395-13	A02135-3-carrier-free	100 ug	carrier-free	$370		Add to Cart

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