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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Transglutaminase 2/TGM2 Antibody Picoband®

SKU : BHA21007353

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Mfr.No.	PA2153, PA2153-10ug, PA2153-Biotin, PA2153-Cy3, PA2153-Dylight488, PA2153-Dylight550, PA2153-Dylight594, PA2153-FITC, PA2153-HRP, PA2153-APC, PA2153-PE, PA2153-iFluor647, PA2153-carrier-free
Alternative Names	Protein-glutamine gamma-glutamyltransferase 2
Background	Tissue transglutaminase, also called TGC, is a 78-kDa, calcium dependent enzyme of the protein-glutamine gamma-glutamyltransferases family. By fluorescence in situ hybridization (FISH), this gene is mapped in 20q11.23. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Transglutaminase 2/TGM2 Antibody catalog # PA2153. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TGM2, different from the related mouse sequence by three amino acids, and from the related rat sequence by four amino acids.
Isotype	Rabbit IgG
Molecular Weight	18 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Protein-glutamine gamma-glutamyltransferase 2;2.3.2.13;Tissue transglutaminase;Transglutaminase C;TG (C);TGC;TGase C;Transglutaminase H;TGase H;Transglutaminase-2;TGase-2;TGM2;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P21980
Gene Name	TGM2
Sequence	Belongs to the transglutaminase superfamily. Transglutaminase family.
Subcellular Location	Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat <br>Immunocytochemistry , 0.5-1ug/ml, Human, -<br>Weste blot, 0.1-0.5ug/ml, Human, Rat<br>

Reference	1. Antonyak, M. A., Jansen, J. M., Miller, A. M., Ly, T. K., Endo, M., Cerione, R. A. Two isoforms of tissue transglutaminase mediate opposing cellular fates. Proc. Nat. Acad. Sci. 103: 18609-18614, 2006.<br /><br />2. Mastroberardino, P. G., Iannicola, C., Nardacci, R., Beassola, F., de Laurenzi, V., Melino, G., Moreno, S., Pavone, F., Oliverio, S., Fesus, L., Piacentini, M. 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Cell Death Differ. 9: 873-880, 2002.<br /><br />3. Priglinger, S. G., May, C. A., Neubauer, A. S., Alge, C. S., Schoenfeld, C.-L., Kampik, A., Welge-Lussen, U. Tissue transglutaminase as a modifying enzyme of the extracellular matrix in PVR membranes. Invest. Ophthal. Vis. Sci. 44: 355-364, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007353-1	PA2153	-	100 ug	$370		Add to Cart
BHA21007353-2	PA2153-10ug	Sample	10 ug	$99		Add to Cart
BHA21007353-3	PA2153-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007353-4	PA2153-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007353-5	PA2153-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007353-6	PA2153-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007353-7	PA2153-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007353-8	PA2153-FITC	FITC	100 ug	$570		Add to Cart
BHA21007353-9	PA2153-HRP	HRP	100 ug	$570		Add to Cart
BHA21007353-10	PA2153-APC	APC	100 ug	$670		Add to Cart
BHA21007353-11	PA2153-PE	PE	100 ug	$670		Add to Cart
BHA21007353-12	PA2153-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007353-13	PA2153-carrier-free	carrier-free	100 ug	$370		Add to Cart

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