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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Transcription factor E2F1 E2F1 Antibody Picoband®

SKU : BHA21006889

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Mfr.No.	PA1560, PA1560-10ug, PA1560-Biotin, PA1560-Cy3, PA1560-Dylight488, PA1560-Dylight550, PA1560-Dylight594, PA1560-FITC, PA1560-HRP, PA1560-APC, PA1560-PE, PA1560-iFluor647, PA1560-carrier-free
Alternative Names	Transcription factor E2F1
Background	Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family of transcription factors appears to play a critical role in the transcription of certain genes required for cell cycle progression. E2F1, the first cloned member of this family, is regulated during the cell cycle at the mRNA level by changes in transcription of the E2F1 gene and at the protein level by complex formation with proteins such as the retinoblastoma gene product (pRB), cyclin A and DP1. E2F1 can override a pRB-induced G1/S block and can behave as an oncogene in certain cells. E2F1 was cloned and was found to contain seven exons. Fluorescence in situ hybridization localized E2F1 to chromosome 20q11. The E2F1 transcription factor can promote proliferation or apoptosis when activated, and is a key downstream target of the retinoblastoma tumour suppressor protein (pRB).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Transcription factor E2F1 E2F1 Antibody catalog # PA1560. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC(CG)CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRT
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human E2F1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Transcription factor E2F1;E2F-1;PBR3;Retinoblastoma-associated protein 1;RBAP-1;Retinoblastoma-binding protein 3;RBBP-3;pRB-binding protein E2F-1;E2F1;RBBP3;
Tissue Specificity	All of the tissues tested and carcinomas.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q01094
Gene Name	E2F1
Sequence	Belongs to the E2F/DP family.
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human , Mouse, Rat<br>

Reference	1. Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr (Dec 1996). "Structure and partial genomic sequence of the human E2F1 gene". Gene 173 (2): 1639.<br /><br />2. Morris, E. J., Ji, J.-Y., Yang, F., DiStefano, L., Herr, A., Moon, N.-S., Kwon, E.-J., Haigis, K. M., Naar, A. M., Dyson, N. J. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 455: 552-556, 2008.<br /><br />3. Neuman, E., Sellers, W. R., McNeil, J. A., Lawrence, J. B., Kaelin, W. G., Jr. Structure and partial genomic sequence of the human E2F1 gene. Gene 173: 163-169, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006889-1	PA1560	-	100 ug	$370		Add to Cart
BHA21006889-2	PA1560-10ug	Sample	10 ug	$99		Add to Cart
BHA21006889-3	PA1560-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006889-4	PA1560-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006889-5	PA1560-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006889-6	PA1560-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006889-7	PA1560-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006889-8	PA1560-FITC	FITC	100 ug	$570		Add to Cart
BHA21006889-9	PA1560-HRP	HRP	100 ug	$570		Add to Cart
BHA21006889-10	PA1560-APC	APC	100 ug	$670		Add to Cart
BHA21006889-11	PA1560-PE	PE	100 ug	$670		Add to Cart
BHA21006889-12	PA1560-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006889-13	PA1560-carrier-free	carrier-free	100 ug	$370		Add to Cart

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