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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Toll-like receptor 8 TLR8 Antibody Picoband®

SKU : BHA21000364

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Mfr.No.	RP1073, RP1073-10ug, RP1073-Biotin, RP1073-Cy3, RP1073-Dylight488, RP1073-Dylight550, RP1073-Dylight594, RP1073-FITC, RP1073-HRP, RP1073-APC, RP1073-PE, RP1073-iFluor647, RP1073-carrier-free
Alternative Names	Toll-like receptor 8
Background	TLR8 (Toll-like receptor 8) is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288 (cluster of differentiation 288).The TLR8 gene is mapped to Xp22.3-p22.2 by Chuang and Ulevitch (2000) and Du et al. (2000). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular pattes (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different pattes of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. TLR8 recognises G-rich oligonucleotides.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Toll-like receptor 8 TLR8 Antibody catalog # RP1073. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular pattes specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cyto
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TLR8, identical to the related mouse sequence.
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Toll-like receptor 8;CD288;TLR8;UNQ249/PRO286;
Tissue Specificity	Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9NR97
Gene Id	51311
Gene Name	TLR8
Sequence	Belongs to the Toll-like receptor family.
Subcellular Location	Membrane ; Single-pass type I membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. Chuang, T.-H., Ulevitch, R. J.Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.Europ. Cytokine Netw. 11: 372-378, 2000. 2. Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., Liu, Y.-J.Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens.J. Exp. Med. 194: 863-869, 2001. 3. Peng, G., Guo, Z., Kiniwa, Y., Voo, K., Peng, W., Fu, T., Wang, D. Y., Li, Y., Wang, H. Y., Wang, R.-F.Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.Science 309: 1380-1384, 2005.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000364-1	RP1073	100 ug	-	$370		Add to Cart
BHA21000364-2	RP1073-10ug	10 ug	Sample	$99		Add to Cart
BHA21000364-3	RP1073-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000364-4	RP1073-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000364-5	RP1073-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000364-6	RP1073-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000364-7	RP1073-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000364-8	RP1073-FITC	100 ug	FITC	$570		Add to Cart
BHA21000364-9	RP1073-HRP	100 ug	HRP	$570		Add to Cart
BHA21000364-10	RP1073-APC	100 ug	APC	$670		Add to Cart
BHA21000364-11	RP1073-PE	100 ug	PE	$670		Add to Cart
BHA21000364-12	RP1073-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000364-13	RP1073-carrier-free	100 ug	carrier-free	$370		Add to Cart

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