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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Toll-like receptor 4 TLR4 Antibody Picoband®

SKU : BHA21006830

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Mfr.No.	PA1484, PA1484-10ug, PA1484-Biotin, PA1484-Cy3, PA1484-Dylight488, PA1484-Dylight550, PA1484-Dylight594, PA1484-FITC, PA1484-HRP, PA1484-APC, PA1484-PE, PA1484-iFluor647, PA1484-carrier-free
Alternative Names	Toll-like receptor 4
Background	TLR4, Toll-like receptor 4, is a protein that in humans is encoded by the TLR4 gene. TLR 4 is a toll-like receptor. TLR4, the human homolog of Drosophila Toll, is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat region and an intracellular domain homologous to that of human interleukin-1 receptor. The TLR4 gene is mapped to chromosome 9q32-q33 by fluorescence in situ hybridization.It detects lipopolysaccharide from Gram-negative bacteria and is thus important in the activation of the innate immune system.The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular pattes (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Toll-like receptor 4 TLR4 Antibody catalog # PA1484. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independe
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human TLR4.
Isotype	Rabbit IgG
Molecular Weight	80 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Toll-like receptor 4;hToll;CD284;TLR4;
Tissue Specificity	Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

Uniprot	O00206
Gene Name	TLR4
Sequence	Belongs to the Toll-like receptor family.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Upon complex formation with CD36 and TLR6, intealized through dynamin-dependent endocytosis. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Medzhitov, R., Preston-Hurlburt, P., Janeway, C. A., Jr.A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.Nature 388: 394-397, 1997.<br /><br />2. Park, B. S., Song, D. H., Kim, H. M., Choi, B.-S., Lee, H., Lee, J.-O.The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.Nature 458: 1191-1195, 2009.<br /><br />3. Rock, F. L., Hardiman, G., Timans, J. C., Kastelein, R. A., Bazan, J. F.A family of human receptors structurally related to Drosophila Toll.Proc. Nat. Acad. Sci. 95: 588-593, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006830-1	PA1484	-	100 ug	$370		Add to Cart
BHA21006830-2	PA1484-10ug	Sample	10 ug	$99		Add to Cart
BHA21006830-3	PA1484-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006830-4	PA1484-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006830-5	PA1484-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006830-6	PA1484-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006830-7	PA1484-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006830-8	PA1484-FITC	FITC	100 ug	$570		Add to Cart
BHA21006830-9	PA1484-HRP	HRP	100 ug	$570		Add to Cart
BHA21006830-10	PA1484-APC	APC	100 ug	$670		Add to Cart
BHA21006830-11	PA1484-PE	PE	100 ug	$670		Add to Cart
BHA21006830-12	PA1484-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006830-13	PA1484-carrier-free	carrier-free	100 ug	$370		Add to Cart

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