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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Toll-like receptor 1 TLR1 Antibody Picoband®

SKU : BHA21002451

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Mfr.No.	A00429-3, A00429-3-10ug, A00429-3-Biotin, A00429-3-Cy3, A00429-3-Dylight488, A00429-3-Dylight550, A00429-3-Dylight594, A00429-3-FITC, A00429-3-HRP, A00429-3-APC, A00429-3-PE, A00429-3-iFluor647, A00429-3-carrier-free
Alternative Names	toll-like receptor 1
Background	Toll-like receptor 1 (TLR1), also called TIL or CD281 is a member of the Toll-like receptor family (TLR) of patte recognition receptors of the innate immune system. This gene is mapped to 4p14 by fluorescence in situ hybridization. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular pattes (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different pattes of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alteative polyadenylation site, and/or from alteative splicing, have been noted for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Toll-like receptor 1 TLR1 Antibody catalog # A00429-3. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation clu
Host	Rabbit
Immunogen Region	E.coli-derived human TLR1 recombinant protein (Position: T62-D404).
Isotype	Rabbit IgG
Molecular Weight	90 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281; TLR1; KIAA0012
Tissue Specificity	Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q15399
Gene Id	7096
Gene Name	TLR1
Subcellular Location	Golgi apparatus. Cell membrane. Single-pass type I membrane protein. Phagosome membrane. Single-pass type I membrane protein. Membrane raft.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IHC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Hart, B. E., Tapping, R. I. Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria. J. Immun. 189: 5347-5355, 2012.<br /><br />2. West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., Ghosh, S. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472: 476-480, 2011.<br /><br />3. Xu, Y., Tao, X., Shen, B., Hog, T., Medzhitov, R., Manley, J. L., Tong, L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408: 111-115, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002451-1	A00429-3	-	100 ug	$370		Add to Cart
BHA21002451-2	A00429-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21002451-3	A00429-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002451-4	A00429-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002451-5	A00429-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002451-6	A00429-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002451-7	A00429-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002451-8	A00429-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21002451-9	A00429-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21002451-10	A00429-3-APC	APC	100 ug	$670		Add to Cart
BHA21002451-11	A00429-3-PE	PE	100 ug	$670		Add to Cart
BHA21002451-12	A00429-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002451-13	A00429-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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