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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TNF Receptor II/TNFRSF1B Antibody Picoband®

SKU : BHA21006697

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Mfr.No.	PA1243, PA1243-10ug, PA1243-Biotin, PA1243-Cy3, PA1243-Dylight488, PA1243-Dylight550, PA1243-Dylight594, PA1243-FITC, PA1243-HRP, PA1243-APC, PA1243-PE, PA1243-iFluor647, PA1243-carrier-free
Alternative Names	Tumor necrosis factor receptor superfamily member 1B
Background	Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TNF Receptor II/TNFRSF1B Antibody catalog # PA1243. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most o
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human TNF Receptor II.
Isotype	Rabbit IgG
Molecular Weight	54 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 1B;Tumor necrosis factor receptor 2;TNF-R2;Tumor necrosis factor receptor type II;TNF-RII;TNFR-II;p75;p80 TNF-alpha receptor;CD120b;Etanercept;Tumor necrosis factor receptor superfamily member 1b, membrane form;Tumor necrosis factor-binding protein 2;TBP-2;TBPII;TNFRSF1B;TNFBR, TNFR2;
Tissue Specificity	Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P20333
Gene Name	TNFRSF1B
Sequence	Contains 4 TNFR-Cys repeats.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Milatovich, A.; Song, K.; Heller, R. A.; Francke, U. : Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat. Cell Molec. Genet. 17: 519-523, 1991. <br /><br />2. Vielhauer, V.; Stavrakis, G.; Mayadas, T. N. : Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J. Clin. Invest. 115: 1199-1209, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006697-1	PA1243	-	100 ug	$370		Add to Cart
BHA21006697-2	PA1243-10ug	Sample	10 ug	$99		Add to Cart
BHA21006697-3	PA1243-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006697-4	PA1243-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006697-5	PA1243-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006697-6	PA1243-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006697-7	PA1243-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006697-8	PA1243-FITC	FITC	100 ug	$570		Add to Cart
BHA21006697-9	PA1243-HRP	HRP	100 ug	$570		Add to Cart
BHA21006697-10	PA1243-APC	APC	100 ug	$670		Add to Cart
BHA21006697-11	PA1243-PE	PE	100 ug	$670		Add to Cart
BHA21006697-12	PA1243-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006697-13	PA1243-carrier-free	carrier-free	100 ug	$370		Add to Cart

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