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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TNF Receptor II/TNFRSF1B Antibody Picoband®

SKU : BHA21000410

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Mfr.No.	PB9515, PB9515-10ug, PB9515-Biotin, PB9515-Cy3, PB9515-Dylight488, PB9515-Dylight550, PB9515-Dylight594, PB9515-FITC, PB9515-HRP, PB9515-APC, PB9515-PE, PB9515-iFluor647, PB9515-carrier-free
Alternative Names	Tumor necrosis factor receptor superfamily member 1B
Background	Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TNF Receptor II/TNFRSF1B Antibody Picoband® catalog # PB9515. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity). .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse TNF Receptor II, different from the related human sequence by eleven amino acids, and from the related rat sequence by six amino acids.
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 1B;Tumor necrosis factor receptor 2;TNF-R2;Tumor necrosis factor receptor type II;TNF-RII;TNFR-II;p75;p80 TNF-alpha receptor;CD120b;Tnfrsf1b;Tnfr-2, Tnfr2;
Tissue Specificity	Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P25119
Gene Id	21938
Gene Name	Tnfrsf1b
Sequence	Contains 4 TNFR-Cys repeats.
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Mouse, Rat

Reference	1. Milatovich, A.; Song, K.; Heller, R. A.; Francke, U. : Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat. Cell Molec. Genet. 17: 519-523, 1991. 2. Vielhauer, V.; Stavrakis, G.; Mayadas, T. N. : Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J. Clin. Invest. 115: 1199-1209, 2005.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000410-1	PB9515	100 ug	-	$370		Add to Cart
BHA21000410-2	PB9515-10ug	10 ug	Sample	$99		Add to Cart
BHA21000410-3	PB9515-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000410-4	PB9515-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000410-5	PB9515-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000410-6	PB9515-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000410-7	PB9515-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000410-8	PB9515-FITC	100 ug	FITC	$570		Add to Cart
BHA21000410-9	PB9515-HRP	100 ug	HRP	$570		Add to Cart
BHA21000410-10	PB9515-APC	100 ug	APC	$670		Add to Cart
BHA21000410-11	PB9515-PE	100 ug	PE	$670		Add to Cart
BHA21000410-12	PB9515-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000410-13	PB9515-carrier-free	100 ug	carrier-free	$370		Add to Cart

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