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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TNF alpha Antibody Picoband®

SKU : BHA21000138

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Mfr.No.	PB9246, PB9246-10ug, PB9246-Biotin, PB9246-Cy3, PB9246-Dylight488, PB9246-Dylight550, PB9246-Dylight594, PB9246-FITC, PB9246-HRP, PB9246-APC, PB9246-PE, PB9246-iFluor647, PB9246-carrier-free
Alternative Names	Tumor necrosis factor
Background	TNFα (Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TNF alpha Antibody Picoband® catalog # PB9246. Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by action or by stimulation of interleukin-1 secretion and is implica
Host	Rabbit
Immunogen Region	E.coli-derived mouse TNF alpha recombinant protein (Position: L80-Q227). Mouse TNF alpha shares 79% and 95% amino acid (aa) sequence identity with human and rat TNF alpha, respectively.
Isotype	Rabbit IgG
Molecular Weight	25 kDa
Reactivity	Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor;Cachectin;TNF-alpha;Tumor necrosis factor ligand superfamily member 2;TNF-a;Tumor necrosis factor, membrane form;N-terminal fragment;NTF;Intracellular domain 1;ICD1;Intracellular domain 2;ICD2;C-domain 1;C-domain 2;Tumor necrosis factor, soluble form;Tnf;Tnfa, Tnfsf2;
Tissue Specificity	Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P06804
Gene Id	21926
Gene Name	TNF
Sequence	Belongs to the IL-15/IL-21 family.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse

Reference	1. Shirai, T., Yamaguchi, H., Ito, H., Todd, C. W., Wallace, R. B.Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.Nature 313: 803-806, 1985. 2. Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., Goeddel, D. V.Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.Nature 312: 724-729, 1984.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000138-1	PB9246	100 ug	-	$370		Add to Cart
BHA21000138-2	PB9246-10ug	10 ug	Sample	$99		Add to Cart
BHA21000138-3	PB9246-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000138-4	PB9246-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000138-5	PB9246-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000138-6	PB9246-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000138-7	PB9246-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000138-8	PB9246-FITC	100 ug	FITC	$570		Add to Cart
BHA21000138-9	PB9246-HRP	100 ug	HRP	$570		Add to Cart
BHA21000138-10	PB9246-APC	100 ug	APC	$670		Add to Cart
BHA21000138-11	PB9246-PE	100 ug	PE	$670		Add to Cart
BHA21000138-12	PB9246-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000138-13	PB9246-carrier-free	100 ug	carrier-free	$370		Add to Cart

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