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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TMEM173 Antibody Picoband®

SKU : BHA21000408

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Mfr.No.	PB9513, PB9513-10ug, PB9513-Biotin, PB9513-Cy3, PB9513-Dylight488, PB9513-Dylight550, PB9513-Dylight594, PB9513-FITC, PB9513-HRP, PB9513-APC, PB9513-PE, PB9513-iFluor647, PB9513-carrier-free
Alternative Names	Stimulator of interferon genes protein
Background	Transmembrane protein 173 is a protein that in humans is encoded by the TMEM173 gene. This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a patte recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. Also the encoded protein has been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alteate splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TMEM173 Antibody Picoband® catalog # PB9513. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TMEM173, different from the related mouse sequence by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	42 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Stimulator of interferon genes protein;hSTING;Endoplasmic reticulum interferon stimulator;ERIS;Mediator of IRF3 activation;hMITA;Transmembrane protein 173;TMEM173;ERIS, MITA, STING;
Tissue Specificity	Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q86WV6
Gene Id	340061
Gene Name	TMEM173
Sequence	Belongs to the transcription factor STAT family.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region. Cytoplasm. In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. "Entrez Gene: Transmembrane protein 173". 2. Ishikawa, H; Barber, G. N. (2008). "STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling".Nature 455 (7213): 6748. 3. Nazmi, A; Mukhopadhyay, R; Dutta, K; Basu, A (2012)."STING mediates neuronal innate immune response following Japanese encephalitis virus infection". Scientific Reports 2: 347.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000408-1	PB9513	100 ug	-	$370		Add to Cart
BHA21000408-2	PB9513-10ug	10 ug	Sample	$99		Add to Cart
BHA21000408-3	PB9513-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000408-4	PB9513-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000408-5	PB9513-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000408-6	PB9513-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000408-7	PB9513-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000408-8	PB9513-FITC	100 ug	FITC	$570		Add to Cart
BHA21000408-9	PB9513-HRP	100 ug	HRP	$570		Add to Cart
BHA21000408-10	PB9513-APC	100 ug	APC	$670		Add to Cart
BHA21000408-11	PB9513-PE	100 ug	PE	$670		Add to Cart
BHA21000408-12	PB9513-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000408-13	PB9513-carrier-free	100 ug	carrier-free	$370		Add to Cart

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