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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TJP2/ZO2 Antibody Picoband®

SKU : BHA21003898

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Mfr.No.	A02774-2, A02774-2-10ug, A02774-2-Biotin, A02774-2-Cy3, A02774-2-Dylight488, A02774-2-Dylight550, A02774-2-Dylight594, A02774-2-FITC, A02774-2-HRP, A02774-2-APC, A02774-2-PE, A02774-2-iFluor647, A02774-2-carrier-free
Alternative Names	CD3e molecule
Background	TJP2(Tight Junction Protein 2), also known as Zona Occludens 2 or ZO2 is a protein that in humans is encoded by the TJP2 gene. Tight junction proteins(TJPs) belong to a family of membrane-associated guanylate kinase(MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. Duclos et al.(1994) mapped the TJP2 gene telomeric to the Friedreich ataxia critical region on chromosome 9q13-q21. TJP2 lies about 70 kb centromeric to the X123 gene and is transcribed in the centromere-to-telomere ion. Using in vitro assays and immunoprecipitation studies, Itoh et al.(1999) showed that the mouse Tjp1, Tjp2, and Tjp3 PDZ1 domains interacted with the C-terminal cytoplasmic domains of Cldn1 through Cldn8. In the mouse inner ear, Walsh et al.(2010) found that Tjp2 expression decreased rapidly between E16.5 and age 1 week to a level in adult mice that was approximately 50% of the level at birth(P0).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TJP2/ZO2 Antibody Picoband® catalog # A02774-2. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane b
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TJP2/ZO2.
Isotype	Rabbit IgG
Molecular Weight	150-170 kDa
Reactivity	Human, Rat, Monkey
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	CD3 antigen, epsilon polypeptide; CD3e molecule; Cd3e; Cd3e_predicted; rCG_58471
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9UDY2
Gene Id	9414
Gene Name	TJP2
Subcellular Location	alpha-beta T cell receptor complex; exteal side of plasma membrane; immunological synapse; cell body; cell-cell junction; dendritic spine; integral component of membrane

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF
Description	Weste blot, 0.25-0.5 ug/ml, Human, Rat, Monkey Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. Duclos, F., Rodius, F., Wrogemann, K., Mandel, J.-L., Koenig, M. The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb. Hum. Molec. Genet. 3: 909-914, 1994. 2. Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., Tsukita, S. binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J. Cell Biol. 147: 1351-1363, 1999. 3. Walsh, T., Pierce, S. B., Lenz, D. R., Brownstein, Z., Dagan-Rosenfeld, O., Shahin, H., Roeb, W., McCarthy, S., Nord, A. S., Gordon, C. R., Ben-Neriah, Z., Sebat, J., Kanaan, M., Lee, M. K., Frydman, M., King, M.-C., Avraham, K. B. Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51. Am. J. Hum. Genet. 87: 101-109, 2010.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003898-1	A02774-2	-	100 ug	$370		Add to Cart
BHA21003898-2	A02774-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003898-3	A02774-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003898-4	A02774-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003898-5	A02774-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003898-6	A02774-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003898-7	A02774-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003898-8	A02774-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003898-9	A02774-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003898-10	A02774-2-APC	APC	100 ug	$670		Add to Cart
BHA21003898-11	A02774-2-PE	PE	100 ug	$670		Add to Cart
BHA21003898-12	A02774-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003898-13	A02774-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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