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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TIMP3 Antibody Picoband®

SKU : BHA21000730

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Mfr.No.	PB9831, PB9831-10ug, PB9831-Biotin, PB9831-Cy3, PB9831-Dylight488, PB9831-Dylight550, PB9831-Dylight594, PB9831-FITC, PB9831-HRP, PB9831-APC, PB9831-PE, PB9831-iFluor647, PB9831-carrier-free
Alternative Names	Metalloproteinase inhibitor 3
Background	Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. It is mapped to 22q12.1-q13.2. This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of theextracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TIMP3 Antibody Picoband® catalog # PB9831. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MM
Host	Rabbit
Immunogen Region	E. coli-derived human TIMP3 recombinant protein (Position: C24-P211). Human TIMP3 shares 97.9% and 97.3% amino acid (aa) sequence identity with mouse and rat TIMP3, respectively.
Isotype	Rabbit IgG
Molecular Weight	34 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Metalloproteinase inhibitor 3;Protein MIG-5;Tissue inhibitor of metalloproteinases 3;TIMP-3;TIMP3;
Tissue Specificity	Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P35625
Gene Id	7078
Gene Name	TIMP3
Subcellular Location	Secreted, extracellular space, extracellular matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	ELISA, 0.1-0.5ug/ml, - Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. "Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)". 2. Apte, S. S.; Mattei, M.-G.; Olsen, B. R. : Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics 19: 86-90, 1994. 3. Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (Apr 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med 9 (4): 40715.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000730-1	PB9831	100 ug	-	$370		Add to Cart
BHA21000730-2	PB9831-10ug	10 ug	Sample	$99		Add to Cart
BHA21000730-3	PB9831-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000730-4	PB9831-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000730-5	PB9831-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000730-6	PB9831-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000730-7	PB9831-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000730-8	PB9831-FITC	100 ug	FITC	$570		Add to Cart
BHA21000730-9	PB9831-HRP	100 ug	HRP	$570		Add to Cart
BHA21000730-10	PB9831-APC	100 ug	APC	$670		Add to Cart
BHA21000730-11	PB9831-PE	100 ug	PE	$670		Add to Cart
BHA21000730-12	PB9831-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000730-13	PB9831-carrier-free	100 ug	carrier-free	$370		Add to Cart

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