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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Thrombopoietin/THPO Antibody Picoband®

SKU : BHA21001007

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Mfr.No.	PB10102, PB10102-10ug, PB10102-Biotin, PB10102-Cy3, PB10102-Dylight488, PB10102-Dylight550, PB10102-Dylight594, PB10102-FITC, PB10102-HRP, PB10102-APC, PB10102-PE, PB10102-iFluor647, PB10102-carrier-free
Alternative Names	Thrombopoietin
Background	Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a protein that in humans is encoded by the THPO gene. Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Thrombopoietin/THPO Antibody Picoband® catalog # PB10102. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Host	Rabbit
Immunogen Region	E. coli-derived human Thrombopoietin/TPO recombinant protein (Position: S22-R258). Human Thrombopoietin/TPO shares 79.3% and 80.6% amino acid (aa) sequence identity with mouse and rat Thrombopoietin/TPO, respectively.
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Thrombopoietin;C-mpl ligand;ML;Megakaryocyte colony-stimulating factor;Megakaryocyte growth and development factor;MGDF;Myeloproliferative leukemia virus oncogene ligand;THPO;MGDF;
Tissue Specificity	Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P40225
Gene Id	7066
Gene Name	THPO
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	ELISA, 0.1-0.5ug/ml, -<br>Western blot, 0.1-0.5ug/ml, Human<br>

Reference	1. "Entrez Gene: THPO thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)".<br /><br />2. Kaushansky K (2006). "Lineage-specific hematopoietic growth factors". N. Engl. J. Med. 354 (19): 203445.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001007-1	PB10102	100 ug	-	$370		Add to Cart
BHA21001007-2	PB10102-10ug	10 ug	Sample	$99		Add to Cart
BHA21001007-3	PB10102-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001007-4	PB10102-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001007-5	PB10102-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001007-6	PB10102-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001007-7	PB10102-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001007-8	PB10102-FITC	100 ug	FITC	$570		Add to Cart
BHA21001007-9	PB10102-HRP	100 ug	HRP	$570		Add to Cart
BHA21001007-10	PB10102-APC	100 ug	APC	$670		Add to Cart
BHA21001007-11	PB10102-PE	100 ug	PE	$670		Add to Cart
BHA21001007-12	PB10102-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001007-13	PB10102-carrier-free	100 ug	carrier-free	$370		Add to Cart

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