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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TGF beta Receptor II/TGFBR2 Antibody Picoband®

SKU : BHA21007124

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Mfr.No.	PA1866, PA1866-10ug, PA1866-Biotin, PA1866-Cy3, PA1866-Dylight488, PA1866-Dylight550, PA1866-Dylight594, PA1866-FITC, PA1866-HRP, PA1866-APC, PA1866-PE, PA1866-iFluor647, PA1866-carrier-free
Alternative Names	TGF-beta receptor type-2
Background	TGFBR2 (transforming growth factor, beta receptor II (70/80kDa)), also known as TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II (TGF-beta receptor type II, TbetaR-II), is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. A TGFBR2 cDNA encoding a deduced 565-amino acid protein with a calculated molecular mass of approximately 60 kD in length. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alteatively spliced transcript variants encoding different isoforms have been characterized. TGFBR2 may be a target of the EWS-FLI1 fusion protein found in Ewing sarcoma and related peripheral primitive neuroectodermal tumors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TGF beta Receptor II/TGFBR2 Antibody catalog # PA1866. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell su
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human TGF beta Receptor II, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	TGF-beta receptor type-2;TGFR-2;2.7.11.30;TGF-beta type II receptor;Transforming growth factor-beta receptor type II;TGF-beta receptor type II;TbetaR-II;TGFBR2;
Tissue Specificity	Abundant in brain.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P37173
Gene Name	TGFBR2
Sequence	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Subcellular Location	Cell membrane ; Single-pass type I membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Hagen, G., Muller, S., Beato, M., Suske, G. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res. 20: 5519-5525, 1992. <br /><br />2. Lin, H. Y., Wang, X.-F., Ng-Eaton, E., Weinberg, R. A., Lodish, H. F. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell 68: 775-785, 1992.<br /><br />3. Hahm, K.-B., Cho, K., Lee, C., Im, Y.-H., Chang, J., Choi, S.-G., Sorensen, P. H. B., Thiele, C. J., Kim, S.-J.Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nature Genet. 23: 222-227, 1999.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007124-1	PA1866	-	100 ug	$370		Add to Cart
BHA21007124-2	PA1866-10ug	Sample	10 ug	$99		Add to Cart
BHA21007124-3	PA1866-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007124-4	PA1866-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007124-5	PA1866-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007124-6	PA1866-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007124-7	PA1866-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007124-8	PA1866-FITC	FITC	100 ug	$570		Add to Cart
BHA21007124-9	PA1866-HRP	HRP	100 ug	$570		Add to Cart
BHA21007124-10	PA1866-APC	APC	100 ug	$670		Add to Cart
BHA21007124-11	PA1866-PE	PE	100 ug	$670		Add to Cart
BHA21007124-12	PA1866-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007124-13	PA1866-carrier-free	carrier-free	100 ug	$370		Add to Cart

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