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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TGF beta Receptor I/TGFBR1 Antibody Picoband®

SKU : BHA21000727

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Mfr.No.	PB9828, PB9828-10ug, PB9828-Biotin, PB9828-Cy3, PB9828-Dylight488, PB9828-Dylight550, PB9828-Dylight594, PB9828-FITC, PB9828-HRP, PB9828-APC, PB9828-PE, PB9828-iFluor647, PB9828-carrier-free
Alternative Names	TGF-beta receptor type-1
Background	Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1. Both are transmembrane serine/threonine receptor kinases. The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest. Vellucci and Reiss (1997) reported that the TGFBR1 gene is approximately 31 kb long and contains 9 exons. The organization of the segment of the gene that encodes the C-terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-TGF beta Receptor I/TGFBR1 Antibody Picoband® catalog # PB9828. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell su
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human TGFBR1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	50-56 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	TGF-beta receptor type-1;TGFR-1;2.7.11.30;Activin A receptor type II-like protein kinase of 53kD;Activin receptor-like kinase 5;ALK-5;ALK5;Serine/threonine-protein kinase receptor R4;SKR4;TGF-beta type I receptor;Transforming growth factor-beta receptor type I;TGF-beta receptor type I;TbetaR-I;TGFBR1;ALK5, SKR4;
Tissue Specificity	Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P36897
Gene Id	7046
Gene Name	TGFBR1
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Drera, B., Tadini, G., Barlati, S., Colombi, M.Identification of a novel TGFBR1 mutation in a Loeys-Dietz syndrome type II patient with vascular Ehlers-Danlos syndrome phenotype. (Letter)Clin. Genet. 73: 290-293, 2008. 2. Goudie, D. R., D'Alessandro, M., Merriman, B., Lee, H., Szeverenyi, I., Avery, S., O'Connor, B. D., Nelson, S. F., Coats, S. E., Stewart, A., Christie, L., Pichert, G., and 11 others.Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1.Nature Genet. 43: 365-369, 2011. 3. Vellucci, V. F., Reiss, M.Cloning and genomic organization of the human transforming growth factor-beta type I receptor gene.Genomics 46: 278-283, 1997.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000727-1	PB9828	100 ug	-	$370		Add to Cart
BHA21000727-2	PB9828-10ug	10 ug	Sample	$99		Add to Cart
BHA21000727-3	PB9828-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000727-4	PB9828-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000727-5	PB9828-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000727-6	PB9828-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000727-7	PB9828-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000727-8	PB9828-FITC	100 ug	FITC	$570		Add to Cart
BHA21000727-9	PB9828-HRP	100 ug	HRP	$570		Add to Cart
BHA21000727-10	PB9828-APC	100 ug	APC	$670		Add to Cart
BHA21000727-11	PB9828-PE	100 ug	PE	$670		Add to Cart
BHA21000727-12	PB9828-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000727-13	PB9828-carrier-free	100 ug	carrier-free	$370		Add to Cart

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