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Home / Primary Antibodies / Polyclonal Antibodies

Anti-TFPI Antibody Picoband®

SKU : BHA21001184

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Mfr.No.	A01052, A01052-10ug, A01052-Biotin, A01052-Cy3, A01052-Dylight488, A01052-Dylight550, A01052-Dylight594, A01052-FITC, A01052-HRP, A01052-APC, A01052-PE, A01052-iFluor647, A01052-carrier-free
Alternative Names	Tissue factor pathway inhibitor
Background	TFPI (Tissue factor pathway inhibitor) also known as EPI, LACI, TFI and TFPT1 is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM. The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TFPI Antibody Picoband® catalog # A01052. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibits factor X (X (a)) ly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quateary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Host	Rabbit
Immunogen Region	E.coli-derived human TFPI recombinant protein (Position: N253-M304). Human TFPI shares 51.1% and 53.2% amino acid (aa) sequence identity with mouse and rat TFPI, respectively.
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tissue factor pathway inhibitor;TFPI;Extrinsic pathway inhibitor;EPI;Lipoprotein-associated coagulation inhibitor;LACI;TFPI;LACI, TFPI1;
Tissue Specificity	Mostly in endothelial cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P10646
Gene Id	7035
Gene Name	TFPI
Subcellular Location	Isoform Alpha: Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Enjyoji, K.-I., Emi, M., Mukai, T., Imada, M., Leppert, M. L., Lalouel, J. M., Kato, H.Human tissue factor pathway inhibitor (TFPI) gene: complete genomic structure and localization on the genetic map of chromosome 2q.Genomics 17: 423-428, 1993.<br /><br />2. Kleesiek, K., Schmidt, M., Gotting, C., Brinkmann, T., Prohaska, W.A first mutation in the human tissue factor pathway inhibitor gene encoding (P151L) TFPI. (Letter)Blood 92: 3976-3977, 1998.<br /><br />3. Lupu, C., Zhu, H., Popescu, N. I., Wren, J. D., Lupu, F.Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen.Blood 118: 4463-4471, 2011.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001184-1	A01052	100 ug	-	$370		Add to Cart
BHA21001184-2	A01052-10ug	10 ug	Sample	$99		Add to Cart
BHA21001184-3	A01052-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001184-4	A01052-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001184-5	A01052-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001184-6	A01052-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001184-7	A01052-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001184-8	A01052-FITC	100 ug	FITC	$570		Add to Cart
BHA21001184-9	A01052-HRP	100 ug	HRP	$570		Add to Cart
BHA21001184-10	A01052-APC	100 ug	APC	$670		Add to Cart
BHA21001184-11	A01052-PE	100 ug	PE	$670		Add to Cart
BHA21001184-12	A01052-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001184-13	A01052-carrier-free	100 ug	carrier-free	$370		Add to Cart

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