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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Tau/MAPT Antibody Picoband®

SKU : BHA21006828

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Mfr.No.	PA1482, PA1482-10ug, PA1482-Biotin, PA1482-Cy3, PA1482-Dylight488, PA1482-Dylight550, PA1482-Dylight594, PA1482-FITC, PA1482-HRP, PA1482-APC, PA1482-PE, PA1482-iFluor647, PA1482-carrier-free
Alternative Names	Microtubule-associated protein tau
Background	MAPT, Microtubule-associated protein tau, appears to be enriched in axons. The MAPT gene is assigned to chromosome 17 by hybridization of a cDNA clone to flow-sorted and spot-blotted chromosomes and to 17q21 by in situ hybridization, containing 16 exons. The tau proteins are the product of alteative splicingfrom a single gene that in humans is designated MAPT. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons in the central nervous system and are less common elsewhere. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Tau/MAPT Antibody catalog # PA1482. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau funct
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Tau, different from the related mouse and rat sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	79 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;MAPT;MAPTL, MTBT1, TAU;
Tissue Specificity	Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P10636
Gene Name	MAPT
Sequence	Contains 4 Tau/MAP repeats.
Subcellular Location	Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Andreadis, A., Brown, W. M., Kosik, K. S.Structure and novel exons of the human tau gene.Biochemistry 31: 10626-10633, 1992.<br /><br />2. Donlon, T. A., Harris, P., Neve, R. L.Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21. (Abstract)Cytogenet. Cell Genet. 46: 607, 1987.<br /><br />3. Rademakers, R., Cruts, M., van Broeckhoven, C.The role of tau (MAPT) in frontotemporal dementia and related tauopathies.Hum. Mutat. 24: 277-295, 2004.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006828-1	PA1482	-	100 ug	$370		Add to Cart
BHA21006828-2	PA1482-10ug	Sample	10 ug	$99		Add to Cart
BHA21006828-3	PA1482-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006828-4	PA1482-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006828-5	PA1482-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006828-6	PA1482-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006828-7	PA1482-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006828-8	PA1482-FITC	FITC	100 ug	$570		Add to Cart
BHA21006828-9	PA1482-HRP	HRP	100 ug	$570		Add to Cart
BHA21006828-10	PA1482-APC	APC	100 ug	$670		Add to Cart
BHA21006828-11	PA1482-PE	PE	100 ug	$670		Add to Cart
BHA21006828-12	PA1482-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006828-13	PA1482-carrier-free	carrier-free	100 ug	$370		Add to Cart

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