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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Tap1 Antibody Picoband®

SKU : BHA21005001

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Mfr.No.	A01123-2, A01123-2-10ug, A01123-2-Biotin, A01123-2-Cy3, A01123-2-Dylight488, A01123-2-Dylight550, A01123-2-Dylight594, A01123-2-FITC, A01123-2-HRP, A01123-2-APC, A01123-2-PE, A01123-2-iFluor647, A01123-2-carrier-free
Alternative Names	CREB regulated transcription coactivator 2
Background	Transporter associated with antigen processing 1 (TAP1) is a protein that in humans is encoded by the TAP1 gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Tap1 Antibody Picoband® catalog # A01123-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently o
Host	Rabbit
Immunogen Region	E.coli-derived mouse Tap1 recombinant protein (Position: E218-D724).
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	CREB-regulated transcription coactivator 2; Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2; CRTC2; TORC2
Tissue Specificity	Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P21958
Gene Id	21354
Gene Name	Tap1
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Mouse<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Mouse<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Cerundolo, V., Alexander, J., Anderson, K., Lamb, C., Cresswell, P., McMichael, A., Gotch, F., Townsend, A. Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature 345: 449-452, 1990.<br /><br />2. Chen, H. L., Gabrilovich, D., Tampe, R., Girgis, K. R., Nadaf, S., Carbone, D. P. A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer. Nature Genet. 13: 210-213, 1996.<br /><br />3. Colonna, M., Bresnahan, M., Bahram, S., Strominger, J. L., Spies, T. Allelic variants of the human putative peptide transporter involved in antigen processing. Proc. Nat. Acad. Sci. 89: 3932-3936, 1992.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005001-1	A01123-2	-	100 ug	$370		Add to Cart
BHA21005001-2	A01123-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21005001-3	A01123-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005001-4	A01123-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005001-5	A01123-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005001-6	A01123-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005001-7	A01123-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005001-8	A01123-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21005001-9	A01123-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21005001-10	A01123-2-APC	APC	100 ug	$670		Add to Cart
BHA21005001-11	A01123-2-PE	PE	100 ug	$670		Add to Cart
BHA21005001-12	A01123-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005001-13	A01123-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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