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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SynCAM/CADM1 Antibody Picoband®

SKU : BHA21007452

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Mfr.No.	PA2294, PA2294-10ug, PA2294-Biotin, PA2294-Cy3, PA2294-Dylight488, PA2294-Dylight550, PA2294-Dylight594, PA2294-FITC, PA2294-HRP, PA2294-APC, PA2294-PE, PA2294-iFluor647, PA2294-carrier-free
Alternative Names	Cell adhesion molecule 1
Background	Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene. This gene is also known as IGSF4, SYNCAM or TSLC1, and it is mapped to 11q23.3. CADM1 functions as a homophilic cell adhesion molecule at the synapse. Expression of the isolated cytoplasmic tail of CADM1 in neurons inhibited synapse assembly. Conversely, expression of full-length CADM1 in nonneuronal cells induced synapse formation by cocultured hippocampal neurons with normal release properties. CADM1 has been shown to interact with EPB41L3.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SynCAM/CADM1 Antibody catalog # PA2294. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Mediates homophilic cell-cell adhesion in a Ca (2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interactio
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SynCAM, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cell adhesion molecule 1;Immunoglobulin superfamily member 4;IgSF4;Nectin-like protein 2;NECL-2;Spermatogenic immunoglobulin superfamily;SgIgSF;Synaptic cell adhesion molecule;SynCAM;Tumor suppressor in lung cancer 1;TSLC-1;CADM1 ;IGSF4 , IGSF4A, NECL2 , SYNCAM , TSLC1 ;
Tissue Specificity	Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9BY67
Gene Name	CADM1
Sequence	Belongs to the nectin family.
Subcellular Location	Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse . Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Biederer, T., Sara, Y., Mozhayeva, M., Atasoy, D., Liu, X., Kavalali, E. T., Sudhof, T. C.SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297: 1525-1531, 2002. <br /><br />2. Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (Feb 2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2". Genomics 62 (2): 13946.<br /><br />3. Yageta, Mika; Kuramochi Masami, Masuda Mari, Fukami Takeshi, Fukuhara Hiroshi, Maruyama Tomoko, Shibuya Masabumi, Murakami Yoshinori (Sep 2002). " association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. (United States) 62 (18): 512933.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007452-1	PA2294	-	100 ug	$370		Add to Cart
BHA21007452-2	PA2294-10ug	Sample	10 ug	$99		Add to Cart
BHA21007452-3	PA2294-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007452-4	PA2294-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007452-5	PA2294-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007452-6	PA2294-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007452-7	PA2294-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007452-8	PA2294-FITC	FITC	100 ug	$570		Add to Cart
BHA21007452-9	PA2294-HRP	HRP	100 ug	$570		Add to Cart
BHA21007452-10	PA2294-APC	APC	100 ug	$670		Add to Cart
BHA21007452-11	PA2294-PE	PE	100 ug	$670		Add to Cart
BHA21007452-12	PA2294-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007452-13	PA2294-carrier-free	carrier-free	100 ug	$370		Add to Cart

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