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Home / Primary Antibodies / Polyclonal Antibodies

Anti-STRADB Antibody Picoband®

SKU : BHA21005237

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Mfr.No.	A05271-2, A05271-2-10ug, A05271-2-Biotin, A05271-2-Cy3, A05271-2-Dylight488, A05271-2-Dylight550, A05271-2-Dylight594, A05271-2-FITC, A05271-2-HRP, A05271-2-APC, A05271-2-PE, A05271-2-iFluor647, A05271-2-carrier-free
Alternative Names	MAF bZIP transcription factor A
Background	STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene. This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-STRADB Antibody Picoband® catalog # A05271-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence.
Host	Rabbit
Immunogen Region	E.coli-derived human STRADB recombinant protein (Position: E24-E411).
Isotype	Rabbit IgG
Molecular Weight	33 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Transcription factor MafA; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1 factor; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; MAFA
Tissue Specificity	Preferentially expressed in regulatory T-cells (Tregs).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9C0K7
Gene Id	55437
Gene Name	STRADB
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug /1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Hadano, S., Yanagisawa, Y., Skaug, J., Fichter, K., Nasir, J., Martindale, D., Koop, B. F., Scherer, S. W., Nicholson, D. W., Rouleau, G. A., Ikeda, J.-E., Hayden, M. R. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. Genomics 71: 200-213, 2001.<br /><br />2. Sanna, M. G., da Silva Correia, J., Luo, Y., Chuang, B., Paulson, L. M., Nguyen, B., Deveraux, Q. L., Ulevitch, R. J. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. J. Biol. Chem. 277: 30454-30462, 2002.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005237-1	A05271-2	-	100 ug	$370		Add to Cart
BHA21005237-2	A05271-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21005237-3	A05271-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005237-4	A05271-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005237-5	A05271-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005237-6	A05271-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005237-7	A05271-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005237-8	A05271-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21005237-9	A05271-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21005237-10	A05271-2-APC	APC	100 ug	$670		Add to Cart
BHA21005237-11	A05271-2-PE	PE	100 ug	$670		Add to Cart
BHA21005237-12	A05271-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005237-13	A05271-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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