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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Stefin B/CSTB Antibody Picoband®

SKU : BHA21007311

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Mfr.No.	PA2106, PA2106-10ug, PA2106-Biotin, PA2106-Cy3, PA2106-Dylight488, PA2106-Dylight550, PA2106-Dylight594, PA2106-FITC, PA2106-HRP, PA2106-APC, PA2106-PE, PA2106-iFluor647, PA2106-carrier-free
Alternative Names	Cystatin-B
Background	Cystatin B (CSTB),also called STFB, is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The cystatin B gene is located on 21q22.3. It is widely distributed and is localized mostly intracellularly, but has been found extracellularly. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is though to be as a protector against the proteinases leaking from lysosomes. A cystatin B multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, CSTB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of CSTB is dependent on the differentiation status of the cell.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Stefin B/CSTB Antibody catalog # PA2106. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Stefin B.
Isotype	Rabbit IgG
Molecular Weight	14 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cystatin-B;CPI-B;Liver thiol proteinase inhibitor;Stefin-B;CSTB;CST6, STFB;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P04080
Gene Name	CSTB
Sequence	Belongs to the cystatin family.
Subcellular Location	Cytoplasm . Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Alakurtti, K., Weber, E., Rinne, R., Theil, G., de Haan, G.-J., Lindhout, D., Salmikangas, P., Saukko, P., Lahtinen, U., Lehesjoki, A.-E. Loss of lysosomal association of cystatin B proteins representing progressive myoclonus epilepsy, EPM1, mutations. Europ. J. Hum. Genet. 13: 208-215, 2005. Note: Erratum: Europ. J. Hum. Genet. 13: 264 only, 2005.<br /><br />2. Antonarakis, S. Personal Communication. Geneva, Switzerland 4/8/1997.<br /><br />3. Bespalova, I. N., Adkins, S., Pranzatelli, M., Burmeister, M. Novel cystatin B mutation and diagnostic PCR assay in an Unverricht-Lundborg progressive myoclonus epilepsy patient. Am. J. Med. Genet. 74: 467-471, 1997.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007311-1	PA2106	-	100 ug	$370		Add to Cart
BHA21007311-2	PA2106-10ug	Sample	10 ug	$99		Add to Cart
BHA21007311-3	PA2106-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007311-4	PA2106-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007311-5	PA2106-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007311-6	PA2106-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007311-7	PA2106-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007311-8	PA2106-FITC	FITC	100 ug	$570		Add to Cart
BHA21007311-9	PA2106-HRP	HRP	100 ug	$570		Add to Cart
BHA21007311-10	PA2106-APC	APC	100 ug	$670		Add to Cart
BHA21007311-11	PA2106-PE	PE	100 ug	$670		Add to Cart
BHA21007311-12	PA2106-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007311-13	PA2106-carrier-free	carrier-free	100 ug	$370		Add to Cart

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