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Home / Primary Antibodies / Polyclonal Antibodies

Anti-STAT5b Antibody Picoband®

SKU : BHA21007105

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Mfr.No.	PA1841, PA1841-10ug, PA1841-Biotin, PA1841-Cy3, PA1841-Dylight488, PA1841-Dylight550, PA1841-Dylight594, PA1841-FITC, PA1841-HRP, PA1841-APC, PA1841-PE, PA1841-iFluor647, PA1841-carrier-free
Alternative Names	Signal transducer and activator of transcription 5B
Background	STAT5B (Signal transducer and activator of transcription 5B) is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available. By FISH, Lin et al. (1996) mapped STAT5B to 17q11.2. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-STAT5b Antibody catalog # PA1841. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human STAT5b, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	95 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Signal transducer and activator of transcription 5B;STAT5B;
Tissue Specificity	Widely expressed. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P51692
Gene Name	STAT5B
Sequence	Belongs to the transcription factor STAT family.
Subcellular Location	Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse <br>

Reference	1. Ambrosio, R., Fimiani, G., Monfregola, J., Sanzari, E., De Felice, N., Saleo, M. C., Pignata, C., D'Urso, M., Ursini, M. V.The structure of human STAT5A and STAT5B genes reveals two regions of nearly identical sequence and an alteative tissue specific STAT5B promoter.Gene 285: 311-318, 2002.<br /><br />2. Aould, C., Philippe, C., Bourdon, V., Gregoire, M. J., Berger, R., Jonveaux, P.The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia.Hum. Molec. Genet. 8: 1741-1749, 1999.<br /><br />3. Lin, J.-X., Mietz, J., Modi, W. S., John, S., Leonard, W. J.Cloning of human Stat5B: reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.J. Biol. Chem. 271: 10738-10744, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007105-1	PA1841	-	100 ug	$370		Add to Cart
BHA21007105-2	PA1841-10ug	Sample	10 ug	$99		Add to Cart
BHA21007105-3	PA1841-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007105-4	PA1841-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007105-5	PA1841-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007105-6	PA1841-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007105-7	PA1841-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007105-8	PA1841-FITC	FITC	100 ug	$570		Add to Cart
BHA21007105-9	PA1841-HRP	HRP	100 ug	$570		Add to Cart
BHA21007105-10	PA1841-APC	APC	100 ug	$670		Add to Cart
BHA21007105-11	PA1841-PE	PE	100 ug	$670		Add to Cart
BHA21007105-12	PA1841-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007105-13	PA1841-carrier-free	carrier-free	100 ug	$370		Add to Cart

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