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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SPG3A/ATL1 Antibody Picoband®

SKU : BHA21003987

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Mfr.No.	A01994-1, A01994-1-10ug, A01994-1-Biotin, A01994-1-Cy3, A01994-1-Dylight488, A01994-1-Dylight550, A01994-1-Dylight594, A01994-1-FITC, A01994-1-HRP, A01994-1-APC, A01994-1-PE, A01994-1-iFluor647, A01994-1-carrier-free
Alternative Names	eukaryotic translation initiation factor 2-alpha kinase 3
Background	Atlastin, or Atlastin-1, is a protein that in humans is encoded by the ATL1 gene. The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SPG3A/ATL1 Antibody Picoband® catalog # A01994-1. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Convert
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human SPG3A/ATL1, which shares 93.8% and 100% amino acid (aa) sequence identity with mouse and rat ATL1, respectively.
Isotype	Rabbit IgG
Molecular Weight	64 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK; EIF2AK3; PEK; PERK
Tissue Specificity	Ubiquitous. A high level expression is seen in secretory tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q8WXF7
Gene Id	51062
Gene Name	ATL1
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	Flow Cytometry, IHC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Abel, A., Fonknechten, N., Hofer, A., Durr, A., Cruaud, C., Voit, T., Weissenbach, J., Brice, A., Klimpe, S., Auburger, G., Hazan, J. Early onset autosomal dominant spastic paraplegia caused by novel mutations in SPG3A. Neurogenetics 5: 239-243, 2004. 2. Beetz, C., Nygren, A. O. H., Deufel, T., Reid, E. An SPG3A whole gene deletion neither co-segregates with disease nor modifies phenotype in a hereditary spastic paraplegia family with a pathogenic SPG4 mutation. (Letter) Neurogenetics 8: 317-318, 2007. 3. D'Amico, A., Tessa, A., Sabino, A., Bertini, E., Santorelli, F. M., Servidei, S. Incomplete penetrance in an SPG3A-linked family with a new mutation in the atlastin gene. Neurology 62: 2138-2139, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003987-1	A01994-1	-	100 ug	$370		Add to Cart
BHA21003987-2	A01994-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003987-3	A01994-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003987-4	A01994-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003987-5	A01994-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003987-6	A01994-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003987-7	A01994-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003987-8	A01994-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003987-9	A01994-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003987-10	A01994-1-APC	APC	100 ug	$670		Add to Cart
BHA21003987-11	A01994-1-PE	PE	100 ug	$670		Add to Cart
BHA21003987-12	A01994-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003987-13	A01994-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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