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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SPARC Antibody Picoband®

SKU : BHA21006906

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Mfr.No.	PA1585, PA1585-10ug, PA1585-Biotin, PA1585-Cy3, PA1585-Dylight488, PA1585-Dylight550, PA1585-Dylight594, PA1585-FITC, PA1585-HRP, PA1585-APC, PA1585-PE, PA1585-iFluor647, PA1585-carrier-free
Alternative Names	SPARC
Background	SPARC, secreted protein acidic and rich in cysteine, also known as Osteonectin is a protein that in humans is encoded by the SPARC gene. The human SPARC gene is 26.5 kb long, and contains 10 exons and 9 introns and is located on chromosome 5q31-q33. SPARC is a glycoprotein of 40 kD. SPARC is an acidic, cysteine-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) an Ca++ binding domains near the glutamic acidic-rich region at the amino terminus (domain I), 2) a cysteine- rich (domain II), 3) a hydrophilic region (domain III) and 4) an EF hand motif at the carboxy terminus region (domain IV). Osteonectin is a glycoprotein in the bone that binds sodium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin over expression and ampullary cancers and chronic pancreatitis has been found.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SPARC Antibody catalog # PA1585. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human SPARC.
Isotype	Rabbit IgG
Molecular Weight	42 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	SPARC;Basement-membrane protein 40;BM-40;Osteonectin;ON;Secreted protein acidic and rich in cysteine;SPARC;ON;
Tissue Specificity	Brain.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P09486
Gene Name	SPARC
Sequence	Belongs to the SPARC family.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane . In or around the basement membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Gilmour, D. T., Lyon, G. J., Carlton, M. B. L., Sanes, J. R., Cunningham, J. M., Anderson, J. R., Hogan, B. L. M., Evans, M. J., Colledge, W. H.Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.EMBO J. 17: 1860-1870, 1998.<br /><br />2. Goldblum, S. E., Ding, X., Funk, S. E., Sage, E. H.SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function.Proc. Nat. Acad. Sci. 91: 3448-3452, 1994.<br /><br />3. Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., Massague, J.Genes that mediate breast cancer metastasis to lung.Nature 436: 518-524, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006906-1	PA1585	-	100 ug	$370		Add to Cart
BHA21006906-2	PA1585-10ug	Sample	10 ug	$99		Add to Cart
BHA21006906-3	PA1585-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006906-4	PA1585-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006906-5	PA1585-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006906-6	PA1585-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006906-7	PA1585-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006906-8	PA1585-FITC	FITC	100 ug	$570		Add to Cart
BHA21006906-9	PA1585-HRP	HRP	100 ug	$570		Add to Cart
BHA21006906-10	PA1585-APC	APC	100 ug	$670		Add to Cart
BHA21006906-11	PA1585-PE	PE	100 ug	$670		Add to Cart
BHA21006906-12	PA1585-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006906-13	PA1585-carrier-free	carrier-free	100 ug	$370		Add to Cart

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