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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SOX7 Antibody Picoband®

SKU : BHA21007448

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Mfr.No.	PA2285, PA2285-10ug, PA2285-Biotin, PA2285-Cy3, PA2285-Dylight488, PA2285-Dylight550, PA2285-Dylight594, PA2285-FITC, PA2285-HRP, PA2285-APC, PA2285-PE, PA2285-iFluor647, PA2285-carrier-free
Alternative Names	Transcription factor SOX-7
Background	SOX7 belongs to SOX gene family and SOX proteins are transcription factors with critical roles in the regulation of diverse developmental processes. This gene is mapped to 8p23.1. SOX7 gene contains at least 2 exons. In cotransfected 293 cells, Sox7 reduced Wnt (see WNT1)/beta-catenin (see CTNNB1)- stimulated transcription. SOX7 is a potent activator of FGF3 transcription. It not only plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium but also blocks further differentiation into blood precursors. And it may be required for the survival of both hematopoietic and endothelial precursors during specification.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SOX7 Antibody catalog # PA2285. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of bo
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human SOX7, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	42 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Transcription factor SOX-7;SOX7;
Tissue Specificity	Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9BT81
Gene Name	SOX7
Sequence	Contains 1 HMG box DNA-binding domain.
Subcellular Location	Nucleus . Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Murakami, A., Shen, H., Ishida, S., Dickson, C. SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J. Biol. Chem. 279: 28564-28573, 2004. <br /><br />2. "Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells." Guo L., Zhong D., Lau S., Liu X., Dong X.Y., Sun X., Yang V.W., Vertino P.M., Moreno C.S., Varma V., Dong J.T., Zhou W. Mol. Cancer Res. 6:1421-1430(2008).<br /><br />3. Takash, W., Canizares, J., Bonneaud, N., Poulat, F., Mattei, M.-G., Jay, P., Berta, P. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signaling. Nucleic Acids Res. 29: 4274-4283, 2001.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007448-1	PA2285	-	100 ug	$370		Add to Cart
BHA21007448-2	PA2285-10ug	Sample	10 ug	$99		Add to Cart
BHA21007448-3	PA2285-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007448-4	PA2285-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007448-5	PA2285-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007448-6	PA2285-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007448-7	PA2285-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007448-8	PA2285-FITC	FITC	100 ug	$570		Add to Cart
BHA21007448-9	PA2285-HRP	HRP	100 ug	$570		Add to Cart
BHA21007448-10	PA2285-APC	APC	100 ug	$670		Add to Cart
BHA21007448-11	PA2285-PE	PE	100 ug	$670		Add to Cart
BHA21007448-12	PA2285-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007448-13	PA2285-carrier-free	carrier-free	100 ug	$370		Add to Cart

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