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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Sodium/bile acid cotransporter SLC10A1 Antibody Picoband®

SKU : BHA21006971

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Mfr.No.	PA1670, PA1670-10ug, PA1670-Biotin, PA1670-Cy3, PA1670-Dylight488, PA1670-Dylight550, PA1670-Dylight594, PA1670-FITC, PA1670-HRP, PA1670-APC, PA1670-PE, PA1670-iFluor647, PA1670-carrier-free
Alternative Names	Sodium/bile acid cotransporter
Background	Na+-taurocholate cotransporting polypeptide (NTCP), also known as SLC10A1 (Solute carrier family 10, member 1), is the major bile acid uptake system in human hepatocytes. NTCP and the ileal transporter ASBT (apical sodium-dependent bile acid transporter) are two sodium-dependent transporters critical for the enterohepatic circulation of bile acids. The hASBT gene is known to be activated by the glucocorticoid receptor (GR). Ho RH et al. indicates functionally important polymorphisms in NTCP exist and that the like lihood of being carriers of such polymorphisms is dependent on ethnicity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Sodium/bile acid cotransporter SLC10A1 Antibody catalog # PA1670. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human SLC10A1, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Sodium/bile acid cotransporter;Cell growth-inhibiting gene 29 protein;Na (+)/bile acid cotransporter;Na (+)/taurocholate transport protein;Sodium/taurocholate cotransporting polypeptide;Solute carrier family 10 member 1;SLC10A1;NTCP;GIG29;
Tissue Specificity	Detected in neutrophils (at protein level). .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q14973
Gene Name	SLC10A1
Sequence	Contains 1 RHD (Rel-like) domain.
Subcellular Location	Membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat <br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Mouse, Rat, By Heat<br>

Reference	1. Eloranta JJ, Jung D, Kullak-Ublick GA (2006). "The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism.". Mol. Endocrinol. 20 (1): 6579.<br /><br />2. Ho RH, Leake BF, Roberts RL, et al. (2004). "Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.". J. Biol. Chem. 279 (8): 721322.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006971-1	PA1670	-	100 ug	$370		Add to Cart
BHA21006971-2	PA1670-10ug	Sample	10 ug	$99		Add to Cart
BHA21006971-3	PA1670-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006971-4	PA1670-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006971-5	PA1670-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006971-6	PA1670-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006971-7	PA1670-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006971-8	PA1670-FITC	FITC	100 ug	$570		Add to Cart
BHA21006971-9	PA1670-HRP	HRP	100 ug	$570		Add to Cart
BHA21006971-10	PA1670-APC	APC	100 ug	$670		Add to Cart
BHA21006971-11	PA1670-PE	PE	100 ug	$670		Add to Cart
BHA21006971-12	PA1670-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006971-13	PA1670-carrier-free	carrier-free	100 ug	$370		Add to Cart

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