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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SNAP23 Antibody Picoband®

SKU : BHA21003976

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Mfr.No.	A02487, A02487-10ug, A02487-Biotin, A02487-Cy3, A02487-Dylight488, A02487-Dylight550, A02487-Dylight594, A02487-FITC, A02487-HRP, A02487-APC, A02487-PE, A02487-iFluor647, A02487-carrier-free
Alternative Names	fatty acid binding protein 1
Background	SNAP23(Synaptosomal-Associated Protein, 23-KD), also called SNAP23A, is a protein that in humans is encoded by the SNAP23 gene. The SNAP23 gene has 8 exons, with the initiation codon located in exon 2. The SNAP23 gene is mapped on 15q15.1-q15.2. The SNAP23 cDNA encodes a 211-amino acid polypeptide with a predicted mass of 23 kD. Its amino acid sequence is 59% identical to that of SNAP25. Northe blot analysis revealed that SNAP23 is ubiquitously expressed. SNAP23 is able to bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins. After relocation, SNAP23 is required for exocytosis, implying a crucial role in promoting membrane fusion. TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells. STX3A and SNAP23 were codistributed at the apical plasma membrane, where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin. SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SNAP23 Antibody Picoband® catalog # A02487. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (By similarity). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involv
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SNAP23, which shares 94.4% amino acid (aa) sequence identity with mouse and rat SNAP23.
Isotype	Rabbit IgG
Molecular Weight	23 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Fatty acid-binding protein, liver; Fatty acid-binding protein 1; Liver-type fatty acid-binding protein; L-FABP; Squalene- and sterol-carrier protein; SCP; Z-protein; p14; Fabp1
Tissue Specificity	Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma. Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	O00161
Gene Id	8773
Gene Name	SNAP23
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	Flow Cytometry, IHC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Guo, Z., Tuer, C., Castle, D. Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell 94: 537-548, 1998. 2. Lazo, P. A., Nadal, M., Ferrer, M., Area, E., Heandez-Torres, J., Nabokina, S. M., Mollinedo, F., Estivill, X. Genomic organization, chromosomal localization, alteative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes. Hum. Genet. 108: 211-215, 2001. 3. Mollinedo, F., Lazo, P. A. Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. Biochem. Biophys. Res. Commun. 231: 808-812, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003976-1	A02487	-	100 ug	$370		Add to Cart
BHA21003976-2	A02487-10ug	Sample	10 ug	$99		Add to Cart
BHA21003976-3	A02487-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003976-4	A02487-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003976-5	A02487-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003976-6	A02487-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003976-7	A02487-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003976-8	A02487-FITC	FITC	100 ug	$570		Add to Cart
BHA21003976-9	A02487-HRP	HRP	100 ug	$570		Add to Cart
BHA21003976-10	A02487-APC	APC	100 ug	$670		Add to Cart
BHA21003976-11	A02487-PE	PE	100 ug	$670		Add to Cart
BHA21003976-12	A02487-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003976-13	A02487-carrier-free	carrier-free	100 ug	$370		Add to Cart

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