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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SMURF 2/SMURF2 Antibody Picoband®

SKU : BHA21000813

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Mfr.No.	RP1102, RP1102-10ug, RP1102-Biotin, RP1102-Cy3, RP1102-Dylight488, RP1102-Dylight550, RP1102-Dylight594, RP1102-FITC, RP1102-HRP, RP1102-APC, RP1102-PE, RP1102-iFluor647, RP1102-carrier-free
Alternative Names	E3 ubiquitin-protein ligase SMURF2
Background	E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. The SMURF2 gene is mapped to chromosome 17q22-q23 based on sequence similarity between the SMURF2 sequence and a genomic contig. SMURF2 is a HECT domain E3 ubiquitin ligase involved in degradation of SMADs, TGF-beta receptor (TGFBR), and other substrates. It also functions in regulation of neuronal and planar cell polarity, induction of senescence, and tumor suppression
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SMURF 2/SMURF2 Antibody catalog # RP1102. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then ly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human SMURF 2, identical to the related mouse sequence.
Isotype	Rabbit IgG
Molecular Weight	86 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	E3 ubiquitin-protein ligase SMURF2;hSMURF2;6.3.2.-;SMAD ubiquitination regulatory factor 2;SMAD-specific E3 ubiquitin-protein ligase 2;SMURF2;
Tissue Specificity	Widely expressed.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9HAU4
Gene Id	64750
Gene Name	SMURF2
Subcellular Location	Nucleus . Cytoplasm . Cell membrane . Membrane raft . Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2". 2. Blank, M., Tang, Y., Yamashita, M., Burkett, S. S., Cheng, S. Y., Zhang, Y. E. A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nature Med. 18: 227-234, 2012. 3. Lin X, Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling". The Joual of Biological Chemistry 275(47): 3681822.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000813-1	RP1102	100 ug	-	$370		Add to Cart
BHA21000813-2	RP1102-10ug	10 ug	Sample	$99		Add to Cart
BHA21000813-3	RP1102-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000813-4	RP1102-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000813-5	RP1102-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000813-6	RP1102-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000813-7	RP1102-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000813-8	RP1102-FITC	100 ug	FITC	$570		Add to Cart
BHA21000813-9	RP1102-HRP	100 ug	HRP	$570		Add to Cart
BHA21000813-10	RP1102-APC	100 ug	APC	$670		Add to Cart
BHA21000813-11	RP1102-PE	100 ug	PE	$670		Add to Cart
BHA21000813-12	RP1102-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000813-13	RP1102-carrier-free	100 ug	carrier-free	$370		Add to Cart

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