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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SMN1/2 Antibody Picoband®

SKU : BHA21000274

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Mfr.No.	PB9398, PB9398-10ug, PB9398-Biotin, PB9398-Cy3, PB9398-Dylight488, PB9398-Dylight550, PB9398-Dylight594, PB9398-FITC, PB9398-HRP, PB9398-APC, PB9398-PE, PB9398-iFluor647, PB9398-carrier-free
Alternative Names	Survival motor neuron protein
Background	This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SMN1/2 Antibody Picoband® catalog # PB9398. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common s
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SMN1/2, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	32 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Survival motor neuron protein;Component of gems 1;Gemin-1;SMN1;SMN, SMNT;SMN2;SMNC;
Tissue Specificity	Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q16637
Gene Id	6606
Gene Name	SMN1
Sequence	Belongs to the SMN family.
Subcellular Location	Cytoplasm. Nucleus, gem. Nucleus, Cajal body. Cytoplasmic granule. Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with Actn at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Blauw, H. M., Baes, C. P., van Vught, P. W. J., van Rheenen, W., Verheul, M., Cuppen, E., Veldink, J. H., van den Berg, L. H. SMN1 gene duplications are associated with sporadic ALS. Neurology 78: 776-780, 2012. 2. Boda, B., Mas, C., Giudicelli, C., Nepote, V., Guimiot, F., Levacher, B., Zvara, A., Santha, M., LeGall, I., Simonneau, M. Survival motor neuron SMN1 and SMN2 gene promoters: identical sequences and differential expression in neurons and non-neuronal cells. Europ. J. Hum. Genet. 12: 729-737, 2004.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000274-1	PB9398	100 ug	-	$370		Add to Cart
BHA21000274-2	PB9398-10ug	10 ug	Sample	$99		Add to Cart
BHA21000274-3	PB9398-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000274-4	PB9398-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000274-5	PB9398-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000274-6	PB9398-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000274-7	PB9398-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000274-8	PB9398-FITC	100 ug	FITC	$570		Add to Cart
BHA21000274-9	PB9398-HRP	100 ug	HRP	$570		Add to Cart
BHA21000274-10	PB9398-APC	100 ug	APC	$670		Add to Cart
BHA21000274-11	PB9398-PE	100 ug	PE	$670		Add to Cart
BHA21000274-12	PB9398-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000274-13	PB9398-carrier-free	100 ug	carrier-free	$370		Add to Cart

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